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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.
Zablocki JA, Elzein E, Li X, Koltun DO, Parkhill EQ, Kobayashi T, Martinez R, Corkey B, Jiang H, Perry T, Kalla R, Notte GT, Saunders O, Graupe M, Lu Y, Venkataramani C, Guerrero J, Perry J, Osier M, Strickley R, Liu G, Wang WQ, Hu L, Li XJ, El-Bizri N, Hirakawa R, Kahlig K, Xie C, Li CH, Dhalla AK, Rajamani S, Mollova N, Soohoo D, Lepist EI, Murray B, Rhodes G, Belardinelli L, Desai MC. Zablocki JA, et al. Among authors: el bizri n. J Med Chem. 2016 Oct 13;59(19):9005-9017. doi: 10.1021/acs.jmedchem.6b00939. Epub 2016 Oct 3. J Med Chem. 2016. PMID: 27690427
Use-dependent block of cardiac late Na(+) current by ranolazine.
Rajamani S, El-Bizri N, Shryock JC, Makielski JC, Belardinelli L. Rajamani S, et al. Heart Rhythm. 2009 Nov;6(11):1625-31. doi: 10.1016/j.hrthm.2009.07.042. Epub 2009 Jul 28. Heart Rhythm. 2009. PMID: 19879541 Free PMC article.
Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin.
Kornyeyev D, El-Bizri N, Hirakawa R, Nguyen S, Viatchenko-Karpinski S, Yao L, Rajamani S, Belardinelli L. Kornyeyev D, et al. Among authors: el bizri n. Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H426-35. doi: 10.1152/ajpheart.00520.2015. Epub 2015 Dec 4. Am J Physiol Heart Circ Physiol. 2016. PMID: 26637557 Free article.
26 results