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Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C, Carpintero M, Diego JE, Barberis M, Garcia-Cerrada S, Soriano JF, Antonysamy S, Atwell S, MacEwan I, Condon B, Sougias C, Wang J, Zhang A, Conners K, Groshong C, Wasserman SR, Koss JW, Witkin JM, Li X, Overshiner C, Wafford KA, Seidel W, Wang XS, Heinz BA, Swanson S, Catlow JT, Bedwell DW, Monn JA, Mitch CH, Ornstein PL. Chappell MD, et al. Among authors: macewan i. J Med Chem. 2016 Dec 22;59(24):10974-10993. doi: 10.1021/acs.jmedchem.6b01119. Epub 2016 Dec 6. J Med Chem. 2016. PMID: 28002967
The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
Zhao X, Allison D, Condon B, Zhang F, Gheyi T, Zhang A, Ashok S, Russell M, MacEwan I, Qian Y, Jamison JA, Luz JG. Zhao X, et al. Among authors: macewan i. J Med Chem. 2013 Feb 14;56(3):963-9. doi: 10.1021/jm301431y. Epub 2013 Jan 29. J Med Chem. 2013. PMID: 23311358
Structural context of disease-associated mutations and putative mechanism of autoinhibition revealed by X-ray crystallographic analysis of the EZH2-SET domain.
Antonysamy S, Condon B, Druzina Z, Bonanno JB, Gheyi T, Zhang F, MacEwan I, Zhang A, Ashok S, Rodgers L, Russell M, Gately Luz J. Antonysamy S, et al. Among authors: macewan i. PLoS One. 2013 Dec 19;8(12):e84147. doi: 10.1371/journal.pone.0084147. eCollection 2013. PLoS One. 2013. PMID: 24367637 Free PMC article.
Correction to The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD(+)) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition.
Zhao X, Allison D, Condon B, Zhang F, Gheyi T, Zhang A, Ashok S, Russell M, MacEwan I, Qian Y, Jamison JA, Luz JG. Zhao X, et al. Among authors: macewan i. J Med Chem. 2016 Mar 10;59(5):2267. doi: 10.1021/acs.jmedchem.6b00130. Epub 2016 Feb 16. J Med Chem. 2016. PMID: 26882000 No abstract available.
Variation in Proton Craniospinal Irradiation Practice Patterns in the United States: A Pediatric Proton Consortium Registry (PPCR) Study.
Connor M, Paulino AC, Ermoian RP, Hartsell WF, Indelicato DJ, Perkins S, Mangona V, DeNunzio N, Laack NN, Hill-Kayser C, Kwok Y, Chang JH, Yock T, MacEwan I. Connor M, et al. Among authors: macewan i. Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):901-912. doi: 10.1016/j.ijrobp.2021.11.016. Epub 2021 Nov 20. Int J Radiat Oncol Biol Phys. 2022. PMID: 34808253
[No title available]
[No authors listed] [No authors listed] PMID: 34700839
Post-treatment neuroendocrine outcomes among pediatric brain tumor patients: Is there a difference between proton and photon therapy?
Yip AT, Yu JD, Huynh-Le MP, Salans M, Unnikrishnan S, Qian AS, Xu R, Kaner R, MacEwan I, Crawford JR, Hattangadi-Gluth JA. Yip AT, et al. Among authors: macewan i. Clin Transl Radiat Oncol. 2022 Feb 25;34:37-41. doi: 10.1016/j.ctro.2022.02.010. eCollection 2022 May. Clin Transl Radiat Oncol. 2022. PMID: 35345865 Free PMC article.
27 results