Medema RH - Search Results

1

APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability.

Sansregret L, Patterson JO, Dewhurst S, López-García C, Koch A, McGranahan N, Chao WCH, Barry DJ, Rowan A, Instrell R, Horswell S, Way M, Howell M, Singleton MR, Medema RH, Nurse P, Petronczki M, Swanton C. Sansregret L, et al. Among authors: medema rh. Cancer Discov. 2017 Feb;7(2):218-233. doi: 10.1158/2159-8290.CD-16-0645. Epub 2017 Jan 9. Cancer Discov. 2017. PMID: 28069571 Free PMC article.

2

Molecular basis underlying resistance to Mps1/TTK inhibitors.

Koch A, Maia A, Janssen A, Medema RH. Koch A, et al. Among authors: medema rh. Oncogene. 2016 May 12;35(19):2518-28. doi: 10.1038/onc.2015.319. Epub 2015 Sep 14. Oncogene. 2016. PMID: 26364596 Free PMC article.

3

Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.

Feringa FM, Krenning L, Koch A, van den Berg J, van den Broek B, Jalink K, Medema RH. Feringa FM, et al. Among authors: medema rh. Nat Commun. 2016 Aug 26;7:12618. doi: 10.1038/ncomms12618. Nat Commun. 2016. PMID: 27561326 Free PMC article.

4

Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.

Hiruma Y, Koch A, Hazraty N, Tsakou F, Medema RH, Joosten RP, Perrakis A. Hiruma Y, et al. Among authors: medema rh. J Biol Chem. 2017 Sep 1;292(35):14496-14504. doi: 10.1074/jbc.M117.783555. Epub 2017 Jul 18. J Biol Chem. 2017. PMID: 28726638 Free PMC article.

5

Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.

van de Weerdt BC, van Vugt MA, Lindon C, Kauw JJ, Rozendaal MJ, Klompmaker R, Wolthuis RM, Medema RH. van de Weerdt BC, et al. Among authors: medema rh. Mol Cell Biol. 2005 Mar;25(5):2031-44. doi: 10.1128/MCB.25.5.2031-2044.2005. Mol Cell Biol. 2005. PMID: 15713655 Free PMC article.

6

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes.

Jelluma N, Brenkman AB, McLeod I, Yates JR 3rd, Cleveland DW, Medema RH, Kops GJ. Jelluma N, et al. Among authors: medema rh. PLoS One. 2008 Jun 11;3(6):e2415. doi: 10.1371/journal.pone.0002415. PLoS One. 2008. PMID: 18545697 Free PMC article.

7

Relaying the checkpoint signal from kinetochore to APC/C.

Medema RH. Medema RH. Dev Cell. 2009 Jan;16(1):6-8. doi: 10.1016/j.devcel.2008.12.008. Dev Cell. 2009. PMID: 19154713 Free article.

8

Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis RM, Yaffe MB, Medema RH, van Vugt MA. van Leuken R, et al. Among authors: medema rh. PLoS One. 2009;4(4):e5282. doi: 10.1371/journal.pone.0005282. Epub 2009 Apr 23. PLoS One. 2009. PMID: 19390576 Free PMC article.

9

The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.

van Zon W, Ogink J, ter Riet B, Medema RH, te Riele H, Wolthuis RM. van Zon W, et al. Among authors: medema rh. J Cell Biol. 2010 Aug 23;190(4):587-602. doi: 10.1083/jcb.200912084. J Cell Biol. 2010. PMID: 20733055 Free PMC article.

10

Genetic instability: tipping the balance.

Janssen A, Medema RH. Janssen A, et al. Among authors: medema rh. Oncogene. 2013 Sep 19;32(38):4459-70. doi: 10.1038/onc.2012.576. Epub 2012 Dec 17. Oncogene. 2013. PMID: 23246960 Review.

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