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Comparison of a new ELISA assay with the flow cytometric assay for platelet vasodilator-associated stimulated phosphoprotein (VASP) phosphorylation in whole blood to assess P2Y(12) inhibition.
Jakubowski JA, Bourguet N, Boulay-Moine D, Sugidachi A, Yamaguchi S, Barragan P, Zhou C, Moulard M. Jakubowski JA, et al. Among authors: sugidachi a. Thromb Haemost. 2012 Feb;107(2):388-95. doi: 10.1160/TH11-04-0282. Epub 2011 Dec 21. Thromb Haemost. 2012. PMID: 22186965
The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite.
Sugidachi A, Ogawa T, Kurihara A, Hagihara K, Jakubowski JA, Hashimoto M, Niitsu Y, Asai F. Sugidachi A, et al. J Thromb Haemost. 2007 Jul;5(7):1545-51. doi: 10.1111/j.1538-7836.2007.02598.x. Epub 2007 Apr 19. J Thromb Haemost. 2007. PMID: 17456192 Free article.
The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities.
Frelinger AL 3rd, Jakubowski JA, Li Y, Barnard MR, Linden MD, Tarnow I, Fox ML, Sugidachi A, Winters KJ, Furman MI, Michelson AD. Frelinger AL 3rd, et al. Among authors: sugidachi a. J Thromb Haemost. 2008 Feb;6(2):359-65. doi: 10.1111/j.1538-7836.2008.02838.x. Epub 2007 Nov 15. J Thromb Haemost. 2008. PMID: 18021304 Free article.
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