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Design and Synthesis of Novel 3-Nitro-1H-1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis.
Pelizaro BI, Batista JCZ, Portapilla GB, das Neves AR, Silva F, Carvalho DB, Shiguemoto CYK, Pessatto LR, Paredes-Gamero EJ, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, Galvão F, Oliveira KMP, Cassemiro NS, Silva DB, Piranda EM, Arruda CCP, de Albuquerque S, Baroni ACM. Pelizaro BI, et al. Among authors: de albuquerque s. J Med Chem. 2024 Feb 22;67(4):2584-2601. doi: 10.1021/acs.jmedchem.3c01745. Epub 2024 Feb 2. J Med Chem. 2024. PMID: 38305199
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole.
Carvalho DB, Costa PAN, Portapilla GB, das Neves AR, Shiguemoto CYK, Pelizaro BI, Silva F, Piranda EM, Arruda CCP, Gaspari PDM, Cardoso IA, Luccas PH, Nonato MC, Lopes NP, de Albuquerque S, Baroni ACM. Carvalho DB, et al. Among authors: de albuquerque s. Eur J Med Chem. 2023 Nov 15;260:115451. doi: 10.1016/j.ejmech.2023.115451. Epub 2023 May 5. Eur J Med Chem. 2023. PMID: 37573209
Trypanosoma cruzi Sirtuin 2 as a Relevant Druggable Target: New Inhibitors Developed by Computer-Aided Drug Design.
Ferreira GM, Kronenberger T, Maltarollo VG, Poso A, de Moura Gatti F, Almeida VM, Marana SR, Lopes CD, Tezuka DY, de Albuquerque S, da Silva Emery F, Trossini GHG. Ferreira GM, et al. Among authors: de albuquerque s. Pharmaceuticals (Basel). 2023 Mar 10;16(3):428. doi: 10.3390/ph16030428. Pharmaceuticals (Basel). 2023. PMID: 36986527 Free PMC article.
199 results