Howard PW - Search Results

1

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.

Pillow TH, Schutten M, Yu SF, Ohri R, Sadowsky J, Poon KA, Solis W, Zhong F, Del Rosario G, Go MAT, Lau J, Yee S, He J, Liu L, Ng C, Xu K, Leipold DD, Kamath AV, Zhang D, Masterson L, Gregson SJ, Howard PW, Fang F, Chen J, Gunzner-Toste J, Kozak KK, Spencer S, Polakis P, Polson AG, Flygare JA, Junutula JR. Pillow TH, et al. Among authors: howard pw. Mol Cancer Ther. 2017 May;16(5):871-878. doi: 10.1158/1535-7163.MCT-16-0641. Epub 2017 Feb 21. Mol Cancer Ther. 2017. PMID: 28223423

2

Effect of C2/C3-endo unsaturation on the cytotoxicity and DNA-binding reactivity of pyrrolo[2,1-c][1,4]benzodiazepines.

Gregson SJ, Howard PW, Barcella S, Nakamya A, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1849-51. doi: 10.1016/s0960-894x(00)00350-4. Bioorg Med Chem Lett. 2000. PMID: 10969983

3

Design and synthesis of novel pyrrolobenzodiazepine (PBD) prodrugs for ADEPT and GDEPT.

Sagnou MJ, Howard PW, Gregson SJ, Eno-Amooquaye E, Burke PJ, Thurston DE. Sagnou MJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2083-6. doi: 10.1016/s0960-894x(00)00404-2. Bioorg Med Chem Lett. 2000. PMID: 10999476

4

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

Gregson SJ, Howard PW, Hartley JA, Brooks NA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. J Med Chem. 2001 Mar 1;44(5):737-48. doi: 10.1021/jm001064n. J Med Chem. 2001. PMID: 11262084

5

Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.

Gregson SJ, Howard PW, Corcoran KE, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2859-62. doi: 10.1016/s0960-894x(01)00560-1. Bioorg Med Chem Lett. 2001. PMID: 11597416

6

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.

Gregson SJ, Howard PW, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2277-80. doi: 10.1016/s0960-894x(03)00436-0. Bioorg Med Chem Lett. 2003. PMID: 12824017

7

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. Among authors: howard pw. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

8

A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.

Chen Z, Gregson SJ, Howard PW, Thurston DE. Chen Z, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1547-9. doi: 10.1016/j.bmcl.2003.12.094. Bioorg Med Chem Lett. 2004. PMID: 15006400

9

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.

Masterson LA, Croker SJ, Jenkins TC, Howard PW, Thurston DE. Masterson LA, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2004 Feb 23;14(4):901-4. doi: 10.1016/j.bmcl.2003.12.017. Bioorg Med Chem Lett. 2004. PMID: 15012990

10

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.

Hartley JA, Spanswick VJ, Brooks N, Clingen PH, McHugh PJ, Hochhauser D, Pedley RB, Kelland LR, Alley MC, Schultz R, Hollingshead MG, Schweikart KM, Tomaszewski JE, Sausville EA, Gregson SJ, Howard PW, Thurston DE. Hartley JA, et al. Among authors: howard pw. Cancer Res. 2004 Sep 15;64(18):6693-9. doi: 10.1158/0008-5472.CAN-03-2941. Cancer Res. 2004. PMID: 15374986

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