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Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4+ T cell responses that impair CD8+ T cell function.
Larocca RA, Provine NM, Aid M, Iampietro MJ, Borducchi EN, Badamchi-Zadeh A, Abbink P, Ng'ang'a D, Bricault CA, Blass E, Penaloza-MacMaster P, Stephenson KE, Barouch DH. Larocca RA, et al. Among authors: provine nm. Sci Immunol. 2016 Nov;1(5):eaaf7643. doi: 10.1126/sciimmunol.aaf7643. Epub 2016 Nov 4. Sci Immunol. 2016. PMID: 28239679 Free PMC article.
Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.
Penaloza-MacMaster P, Barber DL, Wherry EJ, Provine NM, Teigler JE, Parenteau L, Blackmore S, Borducchi EN, Larocca RA, Yates KB, Shen H, Haining WN, Sommerstein R, Pinschewer DD, Ahmed R, Barouch DH. Penaloza-MacMaster P, et al. Among authors: provine nm. Science. 2015 Jan 16;347(6219):278-82. doi: 10.1126/science.aaa2148. Science. 2015. PMID: 25593185 Free PMC article.
43 results