Ratcliffe PJ - Search Results

1

A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism.

Paolini NA, Attwood M, Sondalle SB, Vieira CMDS, van Adrichem AM, di Summa FM, O'Donohue MF, Gleizes PE, Rachuri S, Briggs JW, Fischer R, Ratcliffe PJ, Wlodarski MW, Houtkooper RH, von Lindern M, Kuijpers TW, Dinman JD, Baserga SJ, Cockman ME, MacInnes AW. Paolini NA, et al. Among authors: ratcliffe pj. Am J Hum Genet. 2017 Mar 2;100(3):506-522. doi: 10.1016/j.ajhg.2017.01.034. Am J Hum Genet. 2017. PMID: 28257692 Free PMC article.

2

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. Maxwell PH, et al. Among authors: ratcliffe pj. Nature. 1999 May 20;399(6733):271-5. doi: 10.1038/20459. Nature. 1999. PMID: 10353251

3

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH. Cockman ME, et al. Among authors: ratcliffe pj. J Biol Chem. 2000 Aug 18;275(33):25733-41. doi: 10.1074/jbc.M002740200. J Biol Chem. 2000. PMID: 10823831 Free article.

4

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

Clifford SC, Cockman ME, Smallwood AC, Mole DR, Woodward ER, Maxwell PH, Ratcliffe PJ, Maher ER. Clifford SC, et al. Among authors: ratcliffe pj. Hum Mol Genet. 2001 May 1;10(10):1029-38. doi: 10.1093/hmg/10.10.1029. Hum Mol Genet. 2001. PMID: 11331613

5

Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene.

Wykoff CC, Sotiriou C, Cockman ME, Ratcliffe PJ, Maxwell P, Liu E, Harris AL. Wykoff CC, et al. Among authors: ratcliffe pj. Br J Cancer. 2004 Mar 22;90(6):1235-43. doi: 10.1038/sj.bjc.6601657. Br J Cancer. 2004. PMID: 15026807 Free PMC article.

6

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ. Cockman ME, et al. Among authors: ratcliffe pj. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. doi: 10.1073/pnas.0606877103. Epub 2006 Sep 26. Proc Natl Acad Sci U S A. 2006. PMID: 17003112 Free PMC article.

7

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

Grosfeld A, Stolze IP, Cockman ME, Pugh CW, Edelmann M, Kessler B, Bullock AN, Ratcliffe PJ, Masson N. Grosfeld A, et al. Among authors: ratcliffe pj. J Biol Chem. 2007 May 4;282(18):13264-9. doi: 10.1074/jbc.M611648200. Epub 2007 Mar 5. J Biol Chem. 2007. PMID: 17339318 Free article.

8

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Coleman ML, et al. Among authors: ratcliffe pj. J Biol Chem. 2007 Aug 17;282(33):24027-38. doi: 10.1074/jbc.M704102200. Epub 2007 Jun 15. J Biol Chem. 2007. PMID: 17573339 Free article.

9

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Cockman ME, Webb JD, Kramer HB, Kessler BM, Ratcliffe PJ. Cockman ME, et al. Among authors: ratcliffe pj. Mol Cell Proteomics. 2009 Mar;8(3):535-46. doi: 10.1074/mcp.M800340-MCP200. Epub 2008 Oct 20. Mol Cell Proteomics. 2009. PMID: 18936059 Free PMC article.

10

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.

Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ. Loenarz C, et al. Among authors: ratcliffe pj. Hum Mol Genet. 2010 Jan 15;19(2):217-22. doi: 10.1093/hmg/ddp480. Epub 2009 Oct 19. Hum Mol Genet. 2010. PMID: 19843542 Free PMC article.

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