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CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus.
Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ, Gupta V. Faridi MH, et al. J Clin Invest. 2017 Apr 3;127(4):1271-1283. doi: 10.1172/JCI88442. Epub 2017 Mar 6. J Clin Invest. 2017. PMID: 28263189 Free PMC article.
Integrin CD11b activation drives anti-tumor innate immunity.
Schmid MC, Khan SQ, Kaneda MM, Pathria P, Shepard R, Louis TL, Anand S, Woo G, Leem C, Faridi MH, Geraghty T, Rajagopalan A, Gupta S, Ahmed M, Vazquez-Padron RI, Cheresh DA, Gupta V, Varner JA. Schmid MC, et al. Among authors: faridi mh. Nat Commun. 2018 Dec 19;9(1):5379. doi: 10.1038/s41467-018-07387-4. Nat Commun. 2018. PMID: 30568188 Free PMC article.
Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.
Maiguel D, Faridi MH, Wei C, Kuwano Y, Balla KM, Hernandez D, Barth CJ, Lugo G, Donnelly M, Nayer A, Moita LF, Schürer S, Traver D, Ruiz P, Vazquez-Padron RI, Ley K, Reiser J, Gupta V. Maiguel D, et al. Among authors: faridi mh. Sci Signal. 2011 Sep 6;4(189):ra57. doi: 10.1126/scisignal.2001811. Sci Signal. 2011. PMID: 21900205 Free PMC article.
Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1.
Lee HW, Khan SQ, Khaliqdina S, Altintas MM, Grahammer F, Zhao JL, Koh KH, Tardi NJ, Faridi MH, Geraghty T, Cimbaluk DJ, Susztak K, Moita LF, Baltimore D, Tharaux PL, Huber TB, Kretzler M, Bitzer M, Reiser J, Gupta V. Lee HW, et al. Among authors: faridi mh. J Biol Chem. 2017 Jan 13;292(2):732-747. doi: 10.1074/jbc.M116.753822. Epub 2016 Dec 2. J Biol Chem. 2017. PMID: 27913625 Free PMC article.
Identification of novel agonists of the integrin CD11b/CD18.
Faridi MH, Maiguel D, Barth CJ, Stoub D, Day R, Schürer S, Gupta V. Faridi MH, et al. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6902-6. doi: 10.1016/j.bmcl.2009.10.077. Epub 2009 Oct 22. Bioorg Med Chem Lett. 2009. PMID: 19879752 Free PMC article.
A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.
Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. Lee HW, et al. Among authors: faridi mh. J Am Soc Nephrol. 2015 Nov;26(11):2741-52. doi: 10.1681/ASN.2014090859. Epub 2015 Apr 9. J Am Soc Nephrol. 2015. PMID: 25858967 Free PMC article.
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