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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. Frayling TM, et al. Among authors: melzer d. Science. 2007 May 11;316(5826):889-94. doi: 10.1126/science.1141634. Epub 2007 Apr 12. Science. 2007. PMID: 17434869 Free PMC article.
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Harries LW, et al. Among authors: melzer d. Aging Cell. 2011 Oct;10(5):868-78. doi: 10.1111/j.1474-9726.2011.00726.x. Epub 2011 Jul 19. Aging Cell. 2011. PMID: 21668623 Free PMC article.
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, Bandinelli S, Murray A, Ferrucci L, Singleton AB, Melzer D, Frayling TM. Wood AR, et al. Among authors: melzer d. Hum Mol Genet. 2011 Oct 15;20(20):4082-92. doi: 10.1093/hmg/ddr328. Epub 2011 Jul 28. Hum Mol Genet. 2011. PMID: 21798870 Free PMC article.
Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Galloway T. Melzer D, et al. Environ Health Perspect. 2011 Dec;119(12):1788-93. doi: 10.1289/ehp.1103809. Epub 2011 Aug 10. Environ Health Perspect. 2011. PMID: 21831745 Free PMC article.
Genomics and successful aging: grounds for renewed optimism?
Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D. Pilling LC, et al. Among authors: melzer d. J Gerontol A Biol Sci Med Sci. 2012 May;67(5):511-9. doi: 10.1093/gerona/gls091. Epub 2012 Mar 27. J Gerontol A Biol Sci Med Sci. 2012. PMID: 22454374 Free PMC article. Review.
268 results