Moraga I - Search Results

1

The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity.

Mendoza JL, Schneider WM, Hoffmann HH, Vercauteren K, Jude KM, Xiong A, Moraga I, Horton TM, Glenn JS, de Jong YP, Rice CM, Garcia KC. Mendoza JL, et al. Among authors: moraga i. Immunity. 2017 Mar 21;46(3):379-392. doi: 10.1016/j.immuni.2017.02.017. Immunity. 2017. PMID: 28329704 Free PMC article.

2

Structural linkage between ligand discrimination and receptor activation by type I interferons.

Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, Lee C, Yarden G, Vleck SE, Glenn JS, Nolan GP, Piehler J, Schreiber G, Garcia KC. Thomas C, et al. Among authors: moraga i. Cell. 2011 Aug 19;146(4):621-32. doi: 10.1016/j.cell.2011.06.048. Cell. 2011. PMID: 21854986 Free PMC article.

3

Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'.

Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Levin AM, et al. Among authors: moraga i. Nature. 2012 Mar 25;484(7395):529-33. doi: 10.1038/nature10975. Nature. 2012. PMID: 22446627 Free PMC article.

4

Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila IS, Creusot RJ, Moraga I, Bates DL, Wong MT, Alonso MN, Suhoski MM, Lupardus P, Meier-Schellersheim M, Engleman EG, Utz PJ, Fathman CG, Paul WE, Garcia KC. Junttila IS, et al. Among authors: moraga i. Nat Chem Biol. 2012 Dec;8(12):990-8. doi: 10.1038/nchembio.1096. Epub 2012 Oct 28. Nat Chem Biol. 2012. PMID: 23103943 Free PMC article.

5

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.

Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Ring AM, et al. Among authors: moraga i. Nat Immunol. 2012 Dec;13(12):1187-95. doi: 10.1038/ni.2449. Epub 2012 Oct 28. Nat Immunol. 2012. PMID: 23104097 Free PMC article.

6

Multifarious determinants of cytokine receptor signaling specificity.

Moraga I, Spangler J, Mendoza JL, Garcia KC. Moraga I, et al. Adv Immunol. 2014;121:1-39. doi: 10.1016/B978-0-12-800100-4.00001-5. Adv Immunol. 2014. PMID: 24388212 Free PMC article. Review.

7

Insights into cytokine-receptor interactions from cytokine engineering.

Spangler JB, Moraga I, Mendoza JL, Garcia KC. Spangler JB, et al. Among authors: moraga i. Annu Rev Immunol. 2015;33:139-67. doi: 10.1146/annurev-immunol-032713-120211. Epub 2014 Dec 10. Annu Rev Immunol. 2015. PMID: 25493332 Free PMC article. Review.

8

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands.

Moraga I, Wernig G, Wilmes S, Gryshkova V, Richter CP, Hong WJ, Sinha R, Guo F, Fabionar H, Wehrman TS, Krutzik P, Demharter S, Plo I, Weissman IL, Minary P, Majeti R, Constantinescu SN, Piehler J, Garcia KC. Moraga I, et al. Cell. 2015 Mar 12;160(6):1196-208. doi: 10.1016/j.cell.2015.02.011. Epub 2015 Feb 26. Cell. 2015. PMID: 25728669 Free PMC article.

9

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.

Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC. Moraga I, et al. Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677. Sci Signal. 2015. PMID: 26554818 Free PMC article.

10

Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.

You C, Marquez-Lago TT, Richter CP, Wilmes S, Moraga I, Garcia KC, Leier A, Piehler J. You C, et al. Among authors: moraga i. Sci Adv. 2016 Dec 2;2(12):e1600452. doi: 10.1126/sciadv.1600452. eCollection 2016 Dec. Sci Adv. 2016. PMID: 27957535 Free PMC article.

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