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In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus fumigatus Infection.
Colley T, Alanio A, Kelly SL, Sehra G, Kizawa Y, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Anderson-Dring L, Nakaoki T, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, Cooke M, Bretagne S, King-Underwood J, Murray J, Ito K, Strong P, Rapeport G. Colley T, et al. Among authors: ito k. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02280-16. doi: 10.1128/AAC.02280-16. Print 2017 May. Antimicrob Agents Chemother. 2017. PMID: 28223388 Free PMC article.
Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.
Fordyce EAF, Brookes DW, Lise-Ciana C, Coates MS, Hunt SF, Ito K, King-Underwood J, Onions ST, Parra GF, Rapeport G, Sherbukhin V, Stockwell JA, Strong P, Thomas JC, Murray J. Fordyce EAF, et al. Among authors: ito k. Bioorg Med Chem Lett. 2017 May 15;27(10):2201-2206. doi: 10.1016/j.bmcl.2017.03.053. Epub 2017 Mar 23. Bioorg Med Chem Lett. 2017. PMID: 28372911
Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.
Coates M, Brookes D, Kim YI, Allen H, Fordyce EAF, Meals EA, Colley T, Ciana CL, Parra GF, Sherbukhin V, Stockwell JA, Thomas JC, Hunt SF, Anderson-Dring L, Onions ST, Cass L, Murray PJ, Ito K, Strong P, DeVincenzo JP, Rapeport G. Coates M, et al. Among authors: ito k. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00737-17. doi: 10.1128/AAC.00737-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28652242 Free PMC article.
In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.
Colley T, Sehra G, Chowdhary A, Alanio A, Kelly SL, Kizawa Y, Armstrong-James D, Fisher MC, Warrilow AGS, Parker JE, Kelly DE, Kimura G, Nishimoto Y, Sunose M, Onions S, Crepin D, Lagasse F, Crittall M, Shannon J, McConville M, King-Underwood J, Naylor A, Bretagne S, Murray J, Ito K, Strong P, Rapeport G. Colley T, et al. Among authors: ito k. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e01941-17. doi: 10.1128/AAC.01941-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29439966 Free PMC article.
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.
Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K. Brookes DW, et al. Among authors: ito k. Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2. Br J Pharmacol. 2018. PMID: 29579332 Free PMC article.
Reduced Nasal Viral Load and IFN Responses in Infants with Respiratory Syncytial Virus Bronchiolitis and Respiratory Failure.
Thwaites RS, Coates M, Ito K, Ghazaly M, Feather C, Abdulla F, Tunstall T, Jain P, Cass L, Rapeport G, Hansel TT, Nadel S, Openshaw P. Thwaites RS, et al. Among authors: ito k. Am J Respir Crit Care Med. 2018 Oct 15;198(8):1074-1084. doi: 10.1164/rccm.201712-2567OC. Am J Respir Crit Care Med. 2018. PMID: 29688024 Free PMC article.
Current approaches to the discovery of novel inhaled medicines.
Strong P, Ito K, Murray J, Rapeport G. Strong P, et al. Among authors: ito k. Drug Discov Today. 2018 Oct;23(10):1705-1717. doi: 10.1016/j.drudis.2018.05.017. Epub 2018 May 20. Drug Discov Today. 2018. PMID: 29775668 Free article. Review.
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