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Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.
Pan X, De Aragão CBP, Velasco-Martin JP, Priestman DA, Wu HY, Takahashi K, Yamaguchi K, Sturiale L, Garozzo D, Platt FM, Lamarche-Vane N, Morales CR, Miyagi T, Pshezhetsky AV. Pan X, et al. Among authors: pshezhetsky av. FASEB J. 2017 Aug;31(8):3467-3483. doi: 10.1096/fj.201601299R. Epub 2017 Apr 25. FASEB J. 2017. PMID: 28442549
Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.
Seyrantepe V, Canuel M, Carpentier S, Landry K, Durand S, Liang F, Zeng J, Caqueret A, Gravel RA, Marchesini S, Zwingmann C, Michaud J, Morales CR, Levade T, Pshezhetsky AV. Seyrantepe V, et al. Among authors: pshezhetsky av. Hum Mol Genet. 2008 Jun 1;17(11):1556-68. doi: 10.1093/hmg/ddn043. Epub 2008 Feb 11. Hum Mol Genet. 2008. PMID: 18270209
Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1.
Seyrantepe V, Hinek A, Peng J, Fedjaev M, Ernest S, Kadota Y, Canuel M, Itoh K, Morales CR, Lavoie J, Tremblay J, Pshezhetsky AV. Seyrantepe V, et al. Among authors: pshezhetsky av. Circulation. 2008 Apr 15;117(15):1973-81. doi: 10.1161/CIRCULATIONAHA.107.733212. Epub 2008 Apr 7. Circulation. 2008. PMID: 18391110
Mice doubly-deficient in lysosomal hexosaminidase A and neuraminidase 4 show epileptic crises and rapid neuronal loss.
Seyrantepe V, Lema P, Caqueret A, Dridi L, Bel Hadj S, Carpentier S, Boucher F, Levade T, Carmant L, Gravel RA, Hamel E, Vachon P, Di Cristo G, Michaud JL, Morales CR, Pshezhetsky AV. Seyrantepe V, et al. Among authors: pshezhetsky av. PLoS Genet. 2010 Sep 16;6(9):e1001118. doi: 10.1371/journal.pgen.1001118. PLoS Genet. 2010. PMID: 20862357 Free PMC article.
Positive regulation of insulin signaling by neuraminidase 1.
Dridi L, Seyrantepe V, Fougerat A, Pan X, Bonneil E, Thibault P, Moreau A, Mitchell GA, Heveker N, Cairo CW, Issad T, Hinek A, Pshezhetsky AV. Dridi L, et al. Among authors: pshezhetsky av. Diabetes. 2013 Jul;62(7):2338-46. doi: 10.2337/db12-1825. Epub 2013 Mar 21. Diabetes. 2013. PMID: 23520133 Free PMC article.
126 results