Fretland AJ - Search Results

1

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.

Estridge TB, Dey AB, Reidy C, Yu X, Zhang Y, Hartley M, Milligan PL, Jin N, Kowala MC, Leohr JK, Fretland AJ, Mabry TE, Luffer-Atlas D, Luo MJ. Estridge TB, et al. Among authors: fretland aj. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118. doi: 10.1124/jpet.117.240242. Epub 2017 May 2. J Pharmacol Exp Ther. 2017. PMID: 28465372

2

Evaluation of various static in vitro-in vivo extrapolation models for risk assessment of the CYP3A inhibition potential of an investigational drug.

Vieira ML, Kirby B, Ragueneau-Majlessi I, Galetin A, Chien JY, Einolf HJ, Fahmi OA, Fischer V, Fretland A, Grime K, Hall SD, Higgs R, Plowchalk D, Riley R, Seibert E, Skordos K, Snoeys J, Venkatakrishnan K, Waterhouse T, Obach RS, Berglund EG, Zhang L, Zhao P, Reynolds KS, Huang SM. Vieira ML, et al. Clin Pharmacol Ther. 2014 Feb;95(2):189-98. doi: 10.1038/clpt.2013.187. Epub 2013 Sep 18. Clin Pharmacol Ther. 2014. PMID: 24048277

3

Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.

Partridge KM, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland A, Gooding K, Harvey A, Hughes NE, Kuklish SL, Luz JG, Manninen PR, McGee JE, Mudra DR, Navarro A, Norman BH, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, Weller JM, York JS, Yu XP. Partridge KM, et al. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1478-1483. doi: 10.1016/j.bmcl.2016.11.011. Epub 2016 Nov 7. Bioorg Med Chem Lett. 2017. PMID: 28190634

4

Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.

O'Neil WM, MacArthur RD, Farrough MJ, Doll MA, Fretland AJ, Hein DW, Crane LR, Svensson CK. O'Neil WM, et al. Among authors: fretland aj. J Clin Pharmacol. 2002 Jun;42(6):613-9. doi: 10.1177/00970002042006004. J Clin Pharmacol. 2002. PMID: 12043950

5

Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.

Leff MA, Epstein PN, Doll MA, Fretland AJ, Devanaboyina US, Rustan TD, Hein DW. Leff MA, et al. Among authors: fretland aj. J Pharmacol Exp Ther. 1999 Jul;290(1):182-7. J Pharmacol Exp Ther. 1999. PMID: 10381774

6

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

Kuklish SL, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland AJ, Gooding K, Harvey A, Hughes NE, Luz JG, Manninen PR, McGee JE, Navarro A, Norman BH, Partridge KM, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, York JS, Yu XP. Kuklish SL, et al. Among authors: fretland aj. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4824-4828. doi: 10.1016/j.bmcl.2016.08.023. Epub 2016 Aug 10. Bioorg Med Chem Lett. 2016. PMID: 27554445

7

Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition.

Fretland AJ, Doll MA, Zhu Y, Smith L, Leff MA, Hein DW. Fretland AJ, et al. Cancer Detect Prev. 2002;26(1):10-4. doi: 10.1016/s0361-090x(02)00005-3. Cancer Detect Prev. 2002. PMID: 12088197

8

Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

Fretland AJ, Devanaboyina US, Doll MA, Zhao S, Xiao GH, Hein DW. Fretland AJ, et al. Toxicol Sci. 2003 Aug;74(2):253-9. doi: 10.1093/toxsci/kfg133. Epub 2003 May 28. Toxicol Sci. 2003. PMID: 12773763

9

Tissue distribution of N-acetyltransferase 1 and 2 catalyzing the N-acetylation of 4-aminobiphenyl and O-acetylation of N-hydroxy-4-aminobiphenyl in the congenic rapid and slow acetylator Syrian hamster.

Hein DW, Doll MA, Nerland DE, Fretland AJ. Hein DW, et al. Among authors: fretland aj. Mol Carcinog. 2006 Apr;45(4):230-8. doi: 10.1002/mc.20164. Mol Carcinog. 2006. PMID: 16482518

10

Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens.

Hein DW, Fretland AJ, Doll MA. Hein DW, et al. Among authors: fretland aj. Int J Cancer. 2006 Sep 1;119(5):1208-11. doi: 10.1002/ijc.21957. Int J Cancer. 2006. PMID: 16570281 Free PMC article.

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