Leohr JK - Search Results

1

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.

Estridge TB, Dey AB, Reidy C, Yu X, Zhang Y, Hartley M, Milligan PL, Jin N, Kowala MC, Leohr JK, Fretland AJ, Mabry TE, Luffer-Atlas D, Luo MJ. Estridge TB, et al. Among authors: leohr jk. J Pharmacol Exp Ther. 2017 Jul;362(1):108-118. doi: 10.1124/jpet.117.240242. Epub 2017 May 2. J Pharmacol Exp Ther. 2017. PMID: 28465372

2

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase-1.

Leohr JK, Luffer-Atlas D, Luo MJ, DeBrota DJ, Green C, Mabry TE, Suico JG. Leohr JK, et al. J Clin Pharmacol. 2018 Apr;58(4):412-424. doi: 10.1002/jcph.1032. Epub 2017 Nov 26. J Clin Pharmacol. 2018. PMID: 29178617 Clinical Trial.

3

Impact of Obesity on Postprandial Triglyceride Contribution to Glucose Homeostasis, Assessed with a Semimechanistic Model.

Leohr J, Kjellsson MC. Leohr J, et al. Clin Pharmacol Ther. 2022 Jul;112(1):112-124. doi: 10.1002/cpt.2604. Epub 2022 May 15. Clin Pharmacol Ther. 2022. PMID: 35388464 Free PMC article.

4

Semi-physiological model of postprandial triglyceride response in lean, obese and very obese individuals after a high-fat meal.

Leohr J, Heathman M, Kjellsson MC. Leohr J, et al. Diabetes Obes Metab. 2018 Mar;20(3):660-666. doi: 10.1111/dom.13138. Epub 2017 Dec 4. Diabetes Obes Metab. 2018. PMID: 29072819 Clinical Trial.

5

Postprandial triglyceride reduction following acute treatment of a selective 5-hydroxytryptamine-2c agonist and characterization using a semi-physiological model.

Leohr J, Heathman M, Kjellsson MC. Leohr J, et al. Diabetes Obes Metab. 2021 Apr;23(4):1001-1010. doi: 10.1111/dom.14306. Epub 2021 Jan 20. Diabetes Obes Metab. 2021. PMID: 33368960 Clinical Trial.

6

Evaluation of the Pharmacokinetic Profile of Ultra Rapid Lispro Administered Subcutaneously at Different Injection Sites.

Leohr JK, Dellva MA, LaBell E, Coutant DE, Linnebjerg H. Leohr JK, et al. Clin Ther. 2022 Jun;44(6):836-847. doi: 10.1016/j.clinthera.2022.04.001. Epub 2022 May 13. Clin Ther. 2022. PMID: 35577602 Free article. Clinical Trial.

7

Evaluation of postprandial total triglycerides within the TIGG model for characterizing postprandial response of glucose, insulin, and GLP-1.

Leohr J, Kjellsson MC. Leohr J, et al. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1529-1540. doi: 10.1002/psp4.13030. Epub 2023 Sep 4. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37667531 Free PMC article.

8

Pharmacokinetic and Glucodynamic Responses of Ultra Rapid Lispro vs Lispro Across a Clinically Relevant Range of Subcutaneous Doses in Healthy Subjects.

Leohr J, Dellva MA, LaBell E, Coutant DE, Klein O, Plum-Moerschel L, Zijlstra E, Linnebjerg H. Leohr J, et al. Clin Ther. 2020 Sep;42(9):1762-1777.e4. doi: 10.1016/j.clinthera.2020.07.005. Epub 2020 Sep 6. Clin Ther. 2020. PMID: 32900535 Free article. Clinical Trial.

9

Two Phase 1 dose-escalation studies exploring multiple regimens of litronesib (LY2523355), an Eg5 inhibitor, in patients with advanced cancer.

Infante JR, Patnaik A, Verschraegen CF, Olszanski AJ, Shaheen M, Burris HA, Tolcher AW, Papadopoulos KP, Beeram M, Hynes SM, Leohr J, Lin AB, Li LQ, McGlothlin A, Farrington DL, Westin EH, Cohen RB. Infante JR, et al. Cancer Chemother Pharmacol. 2017 Feb;79(2):315-326. doi: 10.1007/s00280-016-3205-5. Epub 2017 Jan 17. Cancer Chemother Pharmacol. 2017. PMID: 28097385 Clinical Trial.

10

Ultra rapid lispro lowers postprandial glucose and more closely matches normal physiological glucose response compared to other rapid insulin analogues: A phase 1 randomized, crossover study.

Heise T, Linnebjerg H, Coutant D, LaBell E, Zijlstra E, Kapitza C, Bue-Valleskey J, Zhang Q, Dellva MA, Leohr J. Heise T, et al. Diabetes Obes Metab. 2020 Oct;22(10):1789-1798. doi: 10.1111/dom.14094. Epub 2020 Jun 18. Diabetes Obes Metab. 2020. PMID: 32436641 Free PMC article. Clinical Trial.

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