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Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4.
Cohen TS, Pelletier M, Cheng L, Pennini ME, Bonnell J, Cvitkovic R, Chang CS, Xiao X, Cameroni E, Corti D, Semenova E, Warrener P, Sellman BR, Suzich J, Wang Q, Stover CK. Cohen TS, et al. Among authors: sellman br. JCI Insight. 2017 May 4;2(9):e92774. doi: 10.1172/jci.insight.92774. eCollection 2017 May 4. JCI Insight. 2017. PMID: 28469079 Free PMC article.
Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency.
Tkaczyk C, Hua L, Varkey R, Shi Y, Dettinger L, Woods R, Barnes A, MacGill RS, Wilson S, Chowdhury P, Stover CK, Sellman BR. Tkaczyk C, et al. Among authors: sellman br. Clin Vaccine Immunol. 2012 Mar;19(3):377-85. doi: 10.1128/CVI.05589-11. Epub 2012 Jan 11. Clin Vaccine Immunol. 2012. PMID: 22237895 Free PMC article.
Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.
Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR. Hua L, et al. Among authors: sellman br. Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2. Antimicrob Agents Chemother. 2014. PMID: 24295977 Free PMC article.
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, Prokai L, Suzich J, Stover CK, Sellman BR. Hilliard JJ, et al. Among authors: sellman br. Antimicrob Agents Chemother. 2015 Jan;59(1):299-309. doi: 10.1128/AAC.03918-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348518 Free PMC article.
A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.
DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK. DiGiandomenico A, et al. Among authors: sellman br. Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655. Sci Transl Med. 2014. PMID: 25391481
Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.
Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR. Cohen TS, et al. Among authors: sellman br. Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922. Sci Transl Med. 2016. PMID: 26962155
76 results