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Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Aarts SABM, et al. Among authors: den toom m. J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9. J Neuroinflammation. 2017. PMID: 28494768 Free PMC article.
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.
Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E. Seijkens TTP, et al. Among authors: den toom m. J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055. J Am Coll Cardiol. 2018. PMID: 29406859 Free PMC article.
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.
Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E. Aarts SA, et al. Among authors: den toom m. J Pathol. 2019 Apr;247(4):471-480. doi: 10.1002/path.5205. Epub 2019 Jan 30. J Pathol. 2019. PMID: 30471110 Free PMC article.
Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.
van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. van den Berg SM, et al. Among authors: den toom m. Int J Obes (Lond). 2015 May;39(5):782-90. doi: 10.1038/ijo.2014.198. Epub 2014 Nov 13. Int J Obes (Lond). 2015. PMID: 25394307
Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow.
van den Berg SM, Seijkens TT, Kusters PJ, Beckers L, den Toom M, Smeets E, Levels J, de Winther MP, Lutgens E. van den Berg SM, et al. Among authors: den toom m. FASEB J. 2016 May;30(5):1779-88. doi: 10.1096/fj.201500175. Epub 2016 Jan 26. FASEB J. 2016. PMID: 26813974
This implies that the effects of obesity on HSPCs hampers proper functioning of the immune system.-Van den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Beckers, L., den Toom, M., Smeets, E., Levels, J., de Winther, M. ...
This implies that the effects of obesity on HSPCs hampers proper functioning of the immune system.-Van den Berg, S. M., Seijke …
Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.
Aarts SABM, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E. Aarts SABM, et al. Among authors: den toom m. PLoS One. 2018 Aug 10;13(8):e0202150. doi: 10.1371/journal.pone.0202150. eCollection 2018. PLoS One. 2018. PMID: 30096208 Free PMC article.
Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages' transition into a pro-inflammatory state.
Bosmans LA, van Tiel CM, Aarts SABM, Willemsen L, Baardman J, van Os BW, Toom MD, Beckers L, Ahern DJ, Levels JHM, Jongejan A, Moerland PD, Verberk SGS, den Bossche JV, de Winther MMPJ, Weber C, Atzler D, Monaco C, Gerdes N, Shami A, Lutgens E. Bosmans LA, et al. Among authors: toom md, den bossche jv. Cardiovasc Res. 2023 May 22;119(5):1146-1160. doi: 10.1093/cvr/cvac084. Cardiovasc Res. 2023. PMID: 35587037 Free PMC article.
Inhibition of NET Release Fails to Reduce Adipose Tissue Inflammation in Mice.
Braster Q, Silvestre Roig C, Hartwig H, Beckers L, den Toom M, Döring Y, Daemen MJ, Lutgens E, Soehnlein O. Braster Q, et al. Among authors: den toom m. PLoS One. 2016 Oct 4;11(10):e0163922. doi: 10.1371/journal.pone.0163922. eCollection 2016. PLoS One. 2016. PMID: 27701440 Free PMC article.
24 results