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HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
Tharkar-Promod S, Johnson DP, Bennett SE, Dennis EM, Banowsky BG, Jones SS, Shearstone JR, Quayle SN, Min C, Jarpe M, Mosbruger T, Pomicter AD, Miles RR, Chen WY, Bhalla KN, Zweidler-McKay PA, Shrieve DC, Deininger MW, Chandrasekharan MB, Bhaskara S. Tharkar-Promod S, et al. Among authors: shearstone jr. Leukemia. 2018 Jan;32(1):49-60. doi: 10.1038/leu.2017.174. Epub 2017 Jun 5. Leukemia. 2018. PMID: 28579617 Free PMC article.
HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.
Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, Chandrasekharan MB, Bhaskara S. Johnson DP, et al. Among authors: shearstone jr. Oncotarget. 2015 Mar 10;6(7):4863-87. doi: 10.18632/oncotarget.3120. Oncotarget. 2015. PMID: 25605023 Free PMC article.
Integrin β4 regulates SPARC protein to promote invasion.
Gerson KD, Shearstone JR, Maddula VSRK, Seligmann BE, Mercurio AM. Gerson KD, et al. Among authors: shearstone jr. J Biol Chem. 2012 Mar 23;287(13):9835-9844. doi: 10.1074/jbc.M111.317727. Epub 2012 Feb 3. J Biol Chem. 2012. PMID: 22308039 Free PMC article.
19 results