Eldon M - Search Results

1

Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.

Charych D, Khalili S, Dixit V, Kirk P, Chang T, Langowski J, Rubas W, Doberstein SK, Eldon M, Hoch U, Zalevsky J. Charych D, et al. Among authors: eldon m. PLoS One. 2017 Jul 5;12(7):e0179431. doi: 10.1371/journal.pone.0179431. eCollection 2017. PLoS One. 2017. PMID: 28678791 Free PMC article.

2

Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models.

Hoch U, Staschen CM, Johnson RK, Eldon MA. Hoch U, et al. Cancer Chemother Pharmacol. 2014 Dec;74(6):1125-37. doi: 10.1007/s00280-014-2577-7. Epub 2014 Sep 17. Cancer Chemother Pharmacol. 2014. PMID: 25228368 Free PMC article.

3

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer.

Adkins CE, Nounou MI, Hye T, Mohammad AS, Terrell-Hall T, Mohan NK, Eldon MA, Hoch U, Lockman PR. Adkins CE, et al. BMC Cancer. 2015 Oct 13;15:685. doi: 10.1186/s12885-015-1672-4. BMC Cancer. 2015. PMID: 26463521 Free PMC article.

4

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors.

Sy SKB, Chia YL, Gordi T, Hoch U, Eldon MA. Sy SKB, et al. Among authors: eldon ma. Cancer Chemother Pharmacol. 2018 May;81(5):897-909. doi: 10.1007/s00280-018-3562-3. Epub 2018 Mar 21. Cancer Chemother Pharmacol. 2018. PMID: 29564497 Free PMC article.

5

Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study.

Ge X, Henningfield JE, Siddhanti S, Jobes J, Lu L, Xie S, Ziola M, Kelsh D, Vince B, Di Fonzo CJ, Tagliaferri M, Zalevsky J, Doberstein SK, Hoch U, Eldon MA. Ge X, et al. Among authors: eldon ma. Pain Med. 2020 Feb 1;21(2):e114-e126. doi: 10.1093/pm/pnz232. Pain Med. 2020. PMID: 31553457 Clinical Trial.

6

Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration.

Sy SK, Sweeney TD, Ji C, Hoch U, Eldon MA. Sy SK, et al. Among authors: eldon ma. Cancer Chemother Pharmacol. 2017 Jan;79(1):57-67. doi: 10.1007/s00280-016-3192-6. Epub 2016 Nov 30. Cancer Chemother Pharmacol. 2017. PMID: 27904955 Free PMC article.

7

A multicenter, phase I, dose-escalation study to assess the safety, tolerability, and pharmacokinetics of etirinotecan pegol in patients with refractory solid tumors.

Jameson GS, Hamm JT, Weiss GJ, Alemany C, Anthony S, Basche M, Ramanathan RK, Borad MJ, Tibes R, Cohn A, Hinshaw I, Jotte R, Rosen LS, Hoch U, Eldon MA, Medve R, Schroeder K, White E, Von Hoff DD. Jameson GS, et al. Among authors: eldon ma. Clin Cancer Res. 2013 Jan 1;19(1):268-78. doi: 10.1158/1078-0432.CCR-12-1201. Epub 2012 Nov 7. Clin Cancer Res. 2013. PMID: 23136196 Free PMC article. Clinical Trial.

8

Clinical pharmacokinetics and pharmacodynamics of inhaled insulin.

Patton JS, Bukar JG, Eldon MA. Patton JS, et al. Clin Pharmacokinet. 2004;43(12):781-801. doi: 10.2165/00003088-200443120-00002. Clin Pharmacokinet. 2004. PMID: 15355125 Review.

9

Pharmacologic Profile of Naloxegol, a Peripherally Acting µ-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation.

Floettmann E, Bui K, Sostek M, Payza K, Eldon M. Floettmann E, et al. Among authors: eldon m. J Pharmacol Exp Ther. 2017 May;361(2):280-291. doi: 10.1124/jpet.116.239061. Epub 2017 Mar 23. J Pharmacol Exp Ther. 2017. PMID: 28336575 Free PMC article.

10

Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol.

Eldon MA, Kugler AR, Medve RA, Bui K, Butler K, Sostek M. Eldon MA, et al. Clin Pharmacol Drug Dev. 2015 Nov;4(6):442-8. doi: 10.1002/cpdd.204. Epub 2015 Sep 4. Clin Pharmacol Drug Dev. 2015. PMID: 27137716 Clinical Trial.

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