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Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. Misharin AV, et al. Among authors: lam ap. J Exp Med. 2017 Aug 7;214(8):2387-2404. doi: 10.1084/jem.20162152. Epub 2017 Jul 10. J Exp Med. 2017. PMID: 28694385 Free PMC article.
Fat in fibrosis.
Lam AP, Gottardi CJ. Lam AP, et al. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1268-9. doi: 10.1164/rccm.201305-0971LE. Am J Respir Crit Care Med. 2013. PMID: 24236597 Free PMC article. No abstract available.
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Reyfman PA, et al. Among authors: lam ap. Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC. Am J Respir Crit Care Med. 2019. PMID: 30554520 Free PMC article.
Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling.
Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M. Mutlu GM, et al. Among authors: lam ap. Thorax. 2012 Feb;67(2):139-46. doi: 10.1136/thoraxjnl-2011-200717. Epub 2011 Sep 15. Thorax. 2012. PMID: 21921091 Free PMC article.
Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.
Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ. Lam AP, et al. Am J Respir Crit Care Med. 2014 Jul 15;190(2):185-95. doi: 10.1164/rccm.201401-0079OC. Am J Respir Crit Care Med. 2014. PMID: 24921217 Free PMC article.
Vimentin regulates activation of the NLRP3 inflammasome.
dos Santos G, Rogel MR, Baker MA, Troken JR, Urich D, Morales-Nebreda L, Sennello JA, Kutuzov MA, Sitikov A, Davis JM, Lam AP, Cheresh P, Kamp D, Shumaker DK, Budinger GR, Ridge KM. dos Santos G, et al. Among authors: lam ap. Nat Commun. 2015 Mar 12;6:6574. doi: 10.1038/ncomms7574. Nat Commun. 2015. PMID: 25762200 Free PMC article.
64 results