Lin KH - Search Results

1

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.

Anderson GR, Winter PS, Lin KH, Nussbaum DP, Cakir M, Stein EM, Soderquist RS, Crawford L, Leeds JC, Newcomb R, Stepp P, Yip C, Wardell SE, Tingley JP, Ali M, Xu M, Ryan M, McCall SJ, McRee AJ, Counter CM, Der CJ, Wood KC. Anderson GR, et al. Among authors: lin kh. Cell Rep. 2017 Jul 25;20(4):999-1015. doi: 10.1016/j.celrep.2017.07.006. Cell Rep. 2017. PMID: 28746882 Free PMC article.

2

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.

Winter PS, Sarosiek KA, Lin KH, Meggendorfer M, Schnittger S, Letai A, Wood KC. Winter PS, et al. Among authors: lin kh. Sci Signal. 2014 Dec 23;7(357):ra122. doi: 10.1126/scisignal.2005301. Sci Signal. 2014. PMID: 25538080 Free PMC article.

3

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

Misale S, Bozic I, Tong J, Peraza-Penton A, Lallo A, Baldi F, Lin KH, Truini M, Trusolino L, Bertotti A, Di Nicolantonio F, Nowak MA, Zhang L, Wood KC, Bardelli A. Misale S, et al. Among authors: lin kh. Nat Commun. 2015 Sep 22;6:8305. doi: 10.1038/ncomms9305. Nat Commun. 2015. PMID: 26392303 Free PMC article.

4

Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia.

Lin KH, Winter PS, Xie A, Roth C, Martz CA, Stein EM, Anderson GR, Tingley JP, Wood KC. Lin KH, et al. Sci Rep. 2016 Jun 10;6:27696. doi: 10.1038/srep27696. Sci Rep. 2016. PMID: 27283158 Free PMC article.

5

An acoustofluidic trap and transfer approach for organizing a high density single cell array.

Ohiri KA, Kelly ST, Motschman JD, Lin KH, Wood KC, Yellen BB. Ohiri KA, et al. Among authors: lin kh. Lab Chip. 2018 Jul 10;18(14):2124-2133. doi: 10.1039/c8lc00196k. Lab Chip. 2018. PMID: 29931016 Free PMC article.

6

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity.

Soderquist RS, Crawford L, Liu E, Lu M, Agarwal A, Anderson GR, Lin KH, Winter PS, Cakir M, Wood KC. Soderquist RS, et al. Among authors: lin kh. Nat Commun. 2018 Aug 29;9(1):3513. doi: 10.1038/s41467-018-05815-z. Nat Commun. 2018. PMID: 30158527 Free PMC article.

7

Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers.

Ding Y, Gong C, Huang D, Chen R, Sui P, Lin KH, Liang G, Yuan L, Xiang H, Chen J, Yin T, Alexander PB, Wang QF, Song EW, Li QJ, Wood KC, Wang XF. Ding Y, et al. Among authors: lin kh. Nat Commun. 2018 Oct 15;9(1):4274. doi: 10.1038/s41467-018-06651-x. Nat Commun. 2018. PMID: 30323337 Free PMC article.

8

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity.

Lin KH, Xie A, Rutter JC, Ahn YR, Lloyd-Cowden JM, Nichols AG, Soderquist RS, Koves TR, Muoio DM, MacIver NJ, Lamba JK, Pardee TS, McCall CM, Rizzieri DA, Wood KC. Lin KH, et al. Cell Metab. 2019 May 7;29(5):1217-1231.e7. doi: 10.1016/j.cmet.2019.01.011. Epub 2019 Feb 14. Cell Metab. 2019. PMID: 30773463 Free PMC article.

9

Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.

Manzari MT, Anderson GR, Lin KH, Soderquist RS, Çakir M, Zhang M, Moore CE, Skelton RN, Fèvre M, Li X, Bellucci JJ, Wardell SE, Costa SA, Wood KC, Chilkoti A. Manzari MT, et al. Among authors: lin kh. Sci Adv. 2019 Sep 4;5(9):eaaw9162. doi: 10.1126/sciadv.aaw9162. eCollection 2019 Sep. Sci Adv. 2019. PMID: 31517048 Free PMC article.

10

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Lin KH, Rutter JC, Xie A, Pardieu B, Winn ET, Bello RD, Forget A, Itzykson R, Ahn YR, Dai Z, Sobhan RT, Anderson GR, Singleton KR, Decker AE, Winter PS, Locasale JW, Crawford L, Puissant A, Wood KC. Lin KH, et al. Nat Genet. 2020 Apr;52(4):408-417. doi: 10.1038/s41588-020-0590-9. Epub 2020 Mar 16. Nat Genet. 2020. PMID: 32203462 Free PMC article.

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