Gromada J - Search Results

1

A first-in-human pharmacodynamic and pharmacokinetic study of a fully human anti-glucagon receptor monoclonal antibody in normal healthy volunteers.

Kostic A, King TA, Yang F, Chan KC, Yancopoulos GD, Gromada J, Harp JB. Kostic A, et al. Among authors: gromada j. Diabetes Obes Metab. 2018 Feb;20(2):283-291. doi: 10.1111/dom.13075. Epub 2017 Sep 14. Diabetes Obes Metab. 2018. PMID: 28755409 Free PMC article. Clinical Trial.

2

Glucagon orchestrates stress-induced hyperglycaemia.

Harp JB, Yancopoulos GD, Gromada J. Harp JB, et al. Among authors: gromada j. Diabetes Obes Metab. 2016 Jul;18(7):648-53. doi: 10.1111/dom.12668. Epub 2016 May 4. Diabetes Obes Metab. 2016. PMID: 27027662 Free PMC article. Review.

3

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys.

Okamoto H, Kim J, Aglione J, Lee J, Cavino K, Na E, Rafique A, Kim JH, Harp J, Valenzuela DM, Yancopoulos GD, Murphy AJ, Gromada J. Okamoto H, et al. Among authors: gromada j. Endocrinology. 2015 Aug;156(8):2781-94. doi: 10.1210/en.2015-1011. Epub 2015 May 28. Endocrinology. 2015. PMID: 26020795

4

Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.

Okamoto H, Cavino K, Na E, Krumm E, Kim SY, Cheng X, Murphy AJ, Yancopoulos GD, Gromada J. Okamoto H, et al. Among authors: gromada j. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2753-2758. doi: 10.1073/pnas.1621069114. Epub 2017 Jan 23. Proc Natl Acad Sci U S A. 2017. PMID: 28115707 Free PMC article.

5

Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition.

Okamoto H, Cavino K, Na E, Krumm E, Kim S, Stevis PE, Harp J, Murphy AJ, Yancopoulos GD, Gromada J. Okamoto H, et al. Among authors: gromada j. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2747-2752. doi: 10.1073/pnas.1620989114. Epub 2017 Jan 31. Proc Natl Acad Sci U S A. 2017. PMID: 28143927 Free PMC article.

6

ANGPTL8 Blockade With a Monoclonal Antibody Promotes Triglyceride Clearance, Energy Expenditure, and Weight Loss in Mice.

Gusarova V, Banfi S, Alexa-Braun CA, Shihanian LM, Mintah IJ, Lee JS, Xin Y, Su Q, Kamat V, Cohen JC, Hobbs HH, Zambrowicz B, Yancopoulos GD, Murphy AJ, Gromada J. Gusarova V, et al. Among authors: gromada j. Endocrinology. 2017 May 1;158(5):1252-1259. doi: 10.1210/en.2016-1894. Endocrinology. 2017. PMID: 28204173 Free PMC article.

7

Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice.

Kim J, Okamoto H, Huang Z, Anguiano G, Chen S, Liu Q, Cavino K, Xin Y, Na E, Hamid R, Lee J, Zambrowicz B, Unger R, Murphy AJ, Xu Y, Yancopoulos GD, Li WH, Gromada J. Kim J, et al. Among authors: gromada j. Cell Metab. 2017 Jun 6;25(6):1348-1361.e8. doi: 10.1016/j.cmet.2017.05.006. Cell Metab. 2017. PMID: 28591637 Free PMC article.

8

Pseudotime Ordering of Single Human β-Cells Reveals States of Insulin Production and Unfolded Protein Response.

Xin Y, Dominguez Gutierrez G, Okamoto H, Kim J, Lee AH, Adler C, Ni M, Yancopoulos GD, Murphy AJ, Gromada J. Xin Y, et al. Among authors: gromada j. Diabetes. 2018 Sep;67(9):1783-1794. doi: 10.2337/db18-0365. Epub 2018 Jun 27. Diabetes. 2018. PMID: 29950394

9

RNA Sequencing of Single Human Islet Cells Reveals Type 2 Diabetes Genes.

Xin Y, Kim J, Okamoto H, Ni M, Wei Y, Adler C, Murphy AJ, Yancopoulos GD, Lin C, Gromada J. Xin Y, et al. Among authors: gromada j. Cell Metab. 2016 Oct 11;24(4):608-615. doi: 10.1016/j.cmet.2016.08.018. Epub 2016 Sep 22. Cell Metab. 2016. PMID: 27667665 Free article.

10

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse S, Dansky HM, Leader JB, Murray MF, Ritchie MD, Kirchner HL, Habegger L, Lopez A, Penn J, Zhao A, Shao W, Stahl N, Murphy AJ, Hamon S, Bouzelmat A, Zhang R, Shumel B, Pordy R, Gipe D, Herman GA, Sheu WHH, Lee IT, Liang KW, Guo X, Rotter JI, Chen YI, Kraus WE, Shah SH, Damrauer S, Small A, Rader DJ, Wulff AB, Nordestgaard BG, Tybjærg-Hansen A, van den Hoek AM, Princen HMG, Ledbetter DH, Carey DJ, Overton JD, Reid JG, Sasiela WJ, Banerjee P, Shuldiner AR, Borecki IB, Teslovich TM, Yancopoulos GD, Mellis SJ, Gromada J, Baras A. Dewey FE, et al. Among authors: gromada j. N Engl J Med. 2017 Jul 20;377(3):211-221. doi: 10.1056/NEJMoa1612790. Epub 2017 May 24. N Engl J Med. 2017. PMID: 28538136 Free PMC article. Clinical Trial.

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