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Improved survival in rhesus macaques immunized with modified vaccinia virus Ankara recombinants expressing simian immunodeficiency virus envelope correlates with reduction in memory CD4+ T-cell loss and higher titers of neutralizing antibody.
Ourmanov I, Kuwata T, Goeken R, Goldstein S, Iyengar R, Buckler-White A, Lafont B, Hirsch VM. Ourmanov I, et al. J Virol. 2009 Jun;83(11):5388-400. doi: 10.1128/JVI.02598-08. Epub 2009 Mar 25. J Virol. 2009. PMID: 19321617 Free PMC article.
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection.
Klatt NR, Harris LD, Vinton CL, Sung H, Briant JA, Tabb B, Morcock D, McGinty JW, Lifson JD, Lafont BA, Martin MA, Levine AD, Estes JD, Brenchley JM. Klatt NR, et al. Mucosal Immunol. 2010 Jul;3(4):387-98. doi: 10.1038/mi.2010.14. Epub 2010 Mar 31. Mucosal Immunol. 2010. PMID: 20357762 Free PMC article.
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