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Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish.
Xie Y, Kril LM, Yu T, Zhang W, Frasinyuk MS, Bondarenko SP, Kondratyuk KM, Hausman E, Martin ZM, Wyrebek PP, Liu X, Deaciuc A, Dwoskin LP, Chen J, Zhu H, Zhan CG, Sviripa VM, Blackburn J, Watt DS, Liu C. Xie Y, et al. Among authors: frasinyuk ms. Sci Rep. 2019 Apr 23;9(1):6439. doi: 10.1038/s41598-019-42917-0. Sci Rep. 2019. PMID: 31015569 Free PMC article.
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
Tang B, Frasinyuk MS, Chikwana VM, Mahalingan KK, Morgan CA, Segvich DM, Bondarenko SP, Mrug GP, Wyrebek P, Watt DS, DePaoli-Roach AA, Roach PJ, Hurley TD. Tang B, et al. Among authors: frasinyuk ms. J Med Chem. 2020 Apr 9;63(7):3538-3551. doi: 10.1021/acs.jmedchem.9b01851. Epub 2020 Mar 23. J Med Chem. 2020. PMID: 32134266 Free PMC article.
17 results