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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.
Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C; Alzheimer’s Disease Neuroimaging Initiative; Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM. Shi Y, et al. Among authors: yamada k. Nature. 2017 Sep 28;549(7673):523-527. doi: 10.1038/nature24016. Epub 2017 Sep 20. Nature. 2017. PMID: 28959956 Free PMC article.
Antisense reduction of tau in adult mice protects against seizures.
DeVos SL, Goncharoff DK, Chen G, Kebodeaux CS, Yamada K, Stewart FR, Schuler DR, Maloney SE, Wozniak DF, Rigo F, Bennett CF, Cirrito JR, Holtzman DM, Miller TM. DeVos SL, et al. Among authors: yamada k. J Neurosci. 2013 Jul 31;33(31):12887-97. doi: 10.1523/JNEUROSCI.2107-13.2013. J Neurosci. 2013. PMID: 23904623 Free PMC article.
Neuronal activity regulates extracellular tau in vivo.
Yamada K, Holth JK, Liao F, Stewart FR, Mahan TE, Jiang H, Cirrito JR, Patel TK, Hochgräfe K, Mandelkow EM, Holtzman DM. Yamada K, et al. J Exp Med. 2014 Mar 10;211(3):387-93. doi: 10.1084/jem.20131685. Epub 2014 Feb 17. J Exp Med. 2014. PMID: 24534188 Free PMC article.
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Yamada K, Patel TK, Hochgräfe K, Mahan TE, Jiang H, Stewart FR, Mandelkow EM, Holtzman DM. Yamada K, et al. Mol Neurodegener. 2015 Oct 26;10:55. doi: 10.1186/s13024-015-0052-5. Mol Neurodegener. 2015. PMID: 26502977 Free PMC article.
Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.
Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, Serrano JR, Benitez BA, Schmidt RE, Artyomov M, Ulrich JD, Holtzman DM. Shi Y, et al. Among authors: yamada k. Neuron. 2021 Aug 4;109(15):2413-2426.e7. doi: 10.1016/j.neuron.2021.05.034. Epub 2021 Jun 21. Neuron. 2021. PMID: 34157306 Free PMC article.
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