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Page 1
The Molecular Design Research Network.
Coish P, Brooks BW, Gallagher EP, Mills M, Kavanagh TJ, Simcox N, Lasker GA, Botta D, Schmuck SC, Voutchkova-Kostal A, Kostal J, Mullins ML, Nesmith SM, Mellor KE, Corrales J, Kristofco LA, Saari GN, Steele B, Shen LQ, Melnikov F, Zimmerman JB, Anastas PT. Coish P, et al. Toxicol Sci. 2018 Feb 1;161(2):241-248. doi: 10.1093/toxsci/kfx175. Toxicol Sci. 2018. PMID: 28973416 Review.
Kinetics of Glutathione Depletion and Antioxidant Gene Expression as Indicators of Chemical Modes of Action Assessed in Vitro in Mouse Hepatocytes with Enhanced Glutathione Synthesis.
Melnikov F, Botta D, White CC, Schmuck SC, Winfough M, Schaupp CM, Gallagher EP, Brooks BW, Williams ES, Coish P, Anastas PT, Voutchkova-Kostal A, Kostal J, Kavanagh TJ. Melnikov F, et al. Among authors: coish p. Chem Res Toxicol. 2019 Mar 18;32(3):421-436. doi: 10.1021/acs.chemrestox.8b00259. Epub 2019 Jan 7. Chem Res Toxicol. 2019. PMID: 30547568 Free PMC article.
CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish.
Mills MG, Ramsden R, Ma EY, Corrales J, Kristofco LA, Steele WB, Saari GN, Melnikov F, Kostal J, Kavanagh TJ, Zimmerman JB, Voutchkova-Kostal AM, Brooks BW, Coish P, Anastas PT, Gallagher E. Mills MG, et al. Among authors: coish p. Chem Res Toxicol. 2020 Feb 17;33(2):426-435. doi: 10.1021/acs.chemrestox.9b00346. Epub 2020 Jan 8. Chem Res Toxicol. 2020. PMID: 31858786 Free PMC article.
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
Rudolph J, Esler WP, O'connor S, Coish PD, Wickens PL, Brands M, Bierer DE, Bloomquist BT, Bondar G, Chen L, Chuang CY, Claus TH, Fathi Z, Fu W, Khire UR, Kristie JA, Liu XG, Lowe DB, McClure AC, Michels M, Ortiz AA, Ramsden PD, Schoenleber RW, Shelekhin TE, Vakalopoulos A, Tang W, Wang L, Yi L, Gardell SJ, Livingston JN, Sweet LJ, Bullock WH. Rudolph J, et al. Among authors: coish pd. J Med Chem. 2007 Oct 18;50(21):5202-16. doi: 10.1021/jm070071+. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887659
Identification of selective neuropeptide Y2 peptide agonists.
DeCarr LB, Buckholz TM, Coish PD, Fathi Z, Fisk SE, Mays MR, O'Connor SJ, Lumb KJ. DeCarr LB, et al. Among authors: coish pd. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. doi: 10.1016/j.bmcl.2006.10.007. Epub 2006 Oct 7. Bioorg Med Chem Lett. 2007. PMID: 17055726
Substituted indanylacetic acids as PPAR-alpha-gamma activators.
Lowe DB, Bifulco N, Bullock WH, Claus T, Coish P, Dai M, Dela Cruz FE, Dickson D, Fan D, Hoover-Litty H, Li T, Ma X, Mannelly G, Monahan MK, Muegge I, O'Connor S, Rodriguez M, Shelekhin T, Stolle A, Sweet L, Wang M, Wang Y, Zhang C, Zhang HJ, Zhang M, Zhao K, Zhao Q, Zhu J, Zhu L, Tsutsumi M. Lowe DB, et al. Among authors: coish p. Bioorg Med Chem Lett. 2006 Jan 15;16(2):297-301. doi: 10.1016/j.bmcl.2005.10.008. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275080
Total Synthesis of (±)-Nisamycin.
Wipf P, Coish PDG. Wipf P, et al. Among authors: coish pdg. J Org Chem. 1999 Jul 9;64(14):5053-5061. doi: 10.1021/jo990413m. J Org Chem. 1999. PMID: 34237846