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Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.
Kulp DW, Steichen JM, Pauthner M, Hu X, Schiffner T, Liguori A, Cottrell CA, Havenar-Daughton C, Ozorowski G, Georgeson E, Kalyuzhniy O, Willis JR, Kubitz M, Adachi Y, Reiss SM, Shin M, de Val N, Ward AB, Crotty S, Burton DR, Schief WR. Kulp DW, et al. Among authors: burton dr. Nat Commun. 2017 Nov 21;8(1):1655. doi: 10.1038/s41467-017-01549-6. Nat Commun. 2017. PMID: 29162799 Free PMC article.
Broadly cross-reactive HIV-1-neutralizing human monoclonal Fab selected for binding to gp120-CD4-CCR5 complexes.
Moulard M, Phogat SK, Shu Y, Labrijn AF, Xiao X, Binley JM, Zhang MY, Sidorov IA, Broder CC, Robinson J, Parren PW, Burton DR, Dimitrov DS. Moulard M, et al. Among authors: burton dr. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6913-8. doi: 10.1073/pnas.102562599. Epub 2002 May 7. Proc Natl Acad Sci U S A. 2002. PMID: 11997472 Free PMC article.
660 results