Luffer-Atlas D - Search Results

1

Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α.

Lowery CD, Blosser W, Dowless M, Knoche S, Stephens J, Li H, Surguladze D, Loizos N, Luffer-Atlas D, Oakley GJ 3rd, Guo Q, Iyer S, Rubin BP, Stancato L. Lowery CD, et al. Among authors: luffer atlas d. Clin Cancer Res. 2018 Feb 15;24(4):847-857. doi: 10.1158/1078-0432.CCR-17-1258. Epub 2017 Nov 30. Clin Cancer Res. 2018. PMID: 29191969

2

Population Pharmacokinetic Modeling of Olaratumab, an Anti-PDGFRα Human Monoclonal Antibody, in Patients with Advanced and/or Metastatic Cancer.

Mo G, Baldwin JR, Luffer-Atlas D, Ilaria RL Jr, Conti I, Heathman M, Cronier DM. Mo G, et al. Among authors: luffer atlas d. Clin Pharmacokinet. 2018 Mar;57(3):355-365. doi: 10.1007/s40262-017-0562-0. Clin Pharmacokinet. 2018. PMID: 28620891 Free PMC article. Clinical Trial.

3

PDGFRα monoclonal antibody: Assessment of embryo-fetal toxicity and time-dependent placental transfer of a murine surrogate antibody of olaratumab in mice.

Luffer-Atlas D, Reddy VR, Hilbish KG, Grace CE, Breslin WJ. Luffer-Atlas D, et al. Birth Defects Res. 2018 Nov 1;110(18):1358-1371. doi: 10.1002/bdr2.1403. Epub 2018 Oct 27. Birth Defects Res. 2018. PMID: 30367709

4

PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab.

Baracani R, Bhaskaran M, Davis SM, Morford L, Luffer-Atlas D. Baracani R, et al. Among authors: luffer atlas d. Birth Defects Res. 2023 Apr 15;115(7):782-796. doi: 10.1002/bdr2.2169. Epub 2023 Mar 14. Birth Defects Res. 2023. PMID: 36916488

5

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

Gardinier KM, Gernert DL, Porter WJ, Reel JK, Ornstein PL, Spinazze P, Stevens FC, Hahn P, Hollinshead SP, Mayhugh D, Schkeryantz J, Khilevich A, De Frutos O, Gleason SD, Kato AS, Luffer-Atlas D, Desai PV, Swanson S, Burris KD, Ding C, Heinz BA, Need AB, Barth VN, Stephenson GA, Diseroad BA, Woods TA, Yu H, Bredt D, Witkin JM. Gardinier KM, et al. Among authors: luffer atlas d. J Med Chem. 2016 May 26;59(10):4753-68. doi: 10.1021/acs.jmedchem.6b00125. Epub 2016 Apr 29. J Med Chem. 2016. PMID: 27067148

6

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase-1.

Leohr JK, Luffer-Atlas D, Luo MJ, DeBrota DJ, Green C, Mabry TE, Suico JG. Leohr JK, et al. Among authors: luffer atlas d. J Clin Pharmacol. 2018 Apr;58(4):412-424. doi: 10.1002/jcph.1032. Epub 2017 Nov 26. J Clin Pharmacol. 2018. PMID: 29178617 Clinical Trial.

7

Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.

Xu Y, Mayhugh D, Saeed A, Wang X, Thompson RC, Dominianni SJ, Kauffman RF, Singh J, Bean JS, Bensch WR, Barr RJ, Osborne J, Montrose-Rafizadeh C, Zink RW, Yumibe NP, Huang N, Luffer-Atlas D, Rungta D, Maise DE, Mantlo NB. Xu Y, et al. J Med Chem. 2003 Nov 20;46(24):5121-4. doi: 10.1021/jm034173l. J Med Chem. 2003. PMID: 14613314

8

Unique/major human metabolites: why, how, and when to test for safety in animals.

Luffer-Atlas D. Luffer-Atlas D. Drug Metab Rev. 2008;40(3):447-63. doi: 10.1080/03602530802186561. Drug Metab Rev. 2008. PMID: 18642142 Review.

9

Overview of metabolite safety testing from an industry perspective.

Anderson S, Knadler MP, Luffer-Atlas D. Anderson S, et al. Bioanalysis. 2010 Jul;2(7):1249-61. doi: 10.4155/bio.10.67. Bioanalysis. 2010. PMID: 21083238 Review.

10

The effect of hepatic or renal impairment on the pharmacokinetics of edivoxetine, a selective norepinephrine transporter reuptake inhibitor.

Kielbasa W, Tesfaye E, Luffer-Atlas D, Mitchell MI, Turik MA. Kielbasa W, et al. Eur J Clin Pharmacol. 2013 Dec;69(12):2011-9. doi: 10.1007/s00228-013-1572-y. Epub 2013 Aug 17. Eur J Clin Pharmacol. 2013. PMID: 23955175 Free PMC article. Clinical Trial.

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