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Efficient transgenesis and annotated genome sequence of the regenerative flatworm model Macrostomum lignano.
Wudarski J, Simanov D, Ustyantsev K, de Mulder K, Grelling M, Grudniewska M, Beltman F, Glazenburg L, Demircan T, Wunderer J, Qi W, Vizoso DB, Weissert PM, Olivieri D, Mouton S, Guryev V, Aboobaker A, Schärer L, Ladurner P, Berezikov E. Wudarski J, et al. Among authors: qi w. Nat Commun. 2017 Dec 14;8(1):2120. doi: 10.1038/s41467-017-02214-8. Nat Commun. 2017. PMID: 29242515 Free PMC article.
Mutations in DNA polymerase δ subunit 1 co-segregate with CMD2-type resistance to Cassava Mosaic Geminiviruses.
Lim YW, Mansfeld BN, Schläpfer P, Gilbert KB, Narayanan NN, Qi W, Wang Q, Zhong Z, Boyher A, Gehan J, Beyene G, Lin ZD, Esuma W, Feng S, Chanez C, Eggenberger N, Adiga G, Alicai T, Jacobsen SE, Taylor NJ, Gruissem W, Bart RS. Lim YW, et al. Among authors: qi w. Nat Commun. 2022 Jul 7;13(1):3933. doi: 10.1038/s41467-022-31414-0. Nat Commun. 2022. PMID: 35798722 Free PMC article.
In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA.
Villiger L, Rothgangl T, Witzigmann D, Oka R, Lin PJC, Qi W, Janjuha S, Berk C, Ringnalda F, Beattie MB, Stoffel M, Thöny B, Hall J, Rehrauer H, van Boxtel R, Tam YK, Schwank G. Villiger L, et al. Among authors: qi w. Nat Biomed Eng. 2021 Feb;5(2):179-189. doi: 10.1038/s41551-020-00671-z. Epub 2021 Jan 25. Nat Biomed Eng. 2021. PMID: 33495639 Free PMC article.
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: qi w. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
3,378 results