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Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology.
Derada Troletti C, Fontijn RD, Gowing E, Charabati M, van Het Hof B, Didouh I, van der Pol SMA, Geerts D, Prat A, van Horssen J, Kooij G, de Vries HE. Derada Troletti C, et al. Cell Death Dis. 2019 Jan 18;10(2):45. doi: 10.1038/s41419-018-1294-2. Cell Death Dis. 2019. PMID: 30718504 Free PMC article.
The blood-brain barrier in multiple sclerosis: microRNAs as key regulators.
Kamphuis WW, Derada Troletti C, Reijerkerk A, Romero IA, de Vries HE. Kamphuis WW, et al. Among authors: derada troletti c. CNS Neurol Disord Drug Targets. 2015;14(2):157-67. doi: 10.2174/1871527314666150116125246. CNS Neurol Disord Drug Targets. 2015. PMID: 25613507 Review.
Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome.
Derada Troletti C, Enzmann G, Chiurchiù V, Kamermans A, Tietz SM, Norris PC, Jahromi NH, Leuti A, van der Pol SMA, Schouten M, Serhan CN, de Vries HE, Engelhardt B, Kooij G. Derada Troletti C, et al. Cell Rep. 2021 Jun 1;35(9):109201. doi: 10.1016/j.celrep.2021.109201. Cell Rep. 2021. PMID: 34077725 Free PMC article.
Brain endothelial cell expression of SPARCL-1 is specific to chronic multiple sclerosis lesions and is regulated by inflammatory mediators in vitro.
Bridel C, Koel-Simmelink MJA, Peferoen L, Derada Troletti C, Durieux S, Gorter R, Nutma E, Gami P, Iacobaeus E, Brundin L, Kuhle J, Vrenken H, Killestein J, Piersma SR, Pham TV, De Vries HE, Amor S, Jimenez CR, Teunissen CE. Bridel C, et al. Among authors: derada troletti c. Neuropathol Appl Neurobiol. 2018 Jun;44(4):404-416. doi: 10.1111/nan.12412. Epub 2017 Jun 28. Neuropathol Appl Neurobiol. 2018. PMID: 28543098
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. Dusonchet J, et al. Among authors: derada troletti c. Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2. Hum Mol Genet. 2014. PMID: 24794857 Free PMC article.