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Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.
Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, Wolinsky SM, Michael NL, Kirk GD, Buchbinder S, Haas D, Ndung'u T, Goulder P, Parham P, Walker BD, Carlson JM, Carrington M. Ramsuran V, et al. Among authors: parham p. Science. 2018 Jan 5;359(6371):86-90. doi: 10.1126/science.aam8825. Epub 2018 Jan 4. Science. 2018. PMID: 29302013 Free PMC article.
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, O'Brien SJ, Walker BD, Parham P, Deeks SG, McVicar DW, Carrington M. Martin MP, et al. Among authors: parham p. Nat Genet. 2007 Jun;39(6):733-40. doi: 10.1038/ng2035. Epub 2007 May 13. Nat Genet. 2007. PMID: 17496894 Free PMC article.
The shaping of modern human immune systems by multiregional admixture with archaic humans.
Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. Abi-Rached L, et al. Among authors: parham p. Science. 2011 Oct 7;334(6052):89-94. doi: 10.1126/science.1209202. Epub 2011 Aug 25. Science. 2011. PMID: 21868630 Free PMC article.
Class I HLA haplotypes form two schools that educate NK cells in different ways.
Horowitz A, Djaoud Z, Nemat-Gorgani N, Blokhuis J, Hilton HG, Béziat V, Malmberg KJ, Norman PJ, Guethlein LA, Parham P. Horowitz A, et al. Among authors: parham p. Sci Immunol. 2016 Sep;1(3):eaag1672. doi: 10.1126/sciimmunol.aag1672. Epub 2016 Sep 9. Sci Immunol. 2016. PMID: 27868107 Free PMC article.
Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians.
Deng Z, Zhen J, Harrison GF, Zhang G, Chen R, Sun G, Yu Q, Nemat-Gorgani N, Guethlein LA, He L, Tang M, Gao X, Cai S, Palmer WH, Shortt JA, Gignoux CR, Carrington M, Zou H, Parham P, Hong W, Norman PJ. Deng Z, et al. Among authors: parham p. Mol Biol Evol. 2021 May 19;38(6):2582-2596. doi: 10.1093/molbev/msab053. Mol Biol Evol. 2021. PMID: 33616658 Free PMC article.
Immunology. NK cells lose their inhibition.
Parham P. Parham P. Science. 2004 Aug 6;305(5685):786-7. doi: 10.1126/science.1102025. Science. 2004. PMID: 15297654 No abstract available.
595 results