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Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.
Kreutzfeldt M, Bergthaler A, Fernandez M, Brück W, Steinbach K, Vorm M, Coras R, Blümcke I, Bonilla WV, Fleige A, Forman R, Müller W, Becher B, Misgeld T, Kerschensteiner M, Pinschewer DD, Merkler D. Kreutzfeldt M, et al. Among authors: merkler d. J Exp Med. 2013 Sep 23;210(10):2087-103. doi: 10.1084/jem.20122143. Epub 2013 Sep 2. J Exp Med. 2013. PMID: 23999498 Free PMC article.
Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage.
Bhattacharya A, Hegazy AN, Deigendesch N, Kosack L, Cupovic J, Kandasamy RK, Hildebrandt A, Merkler D, Kühl AA, Vilagos B, Schliehe C, Panse I, Khamina K, Baazim H, Arnold I, Flatz L, Xu HC, Lang PA, Aderem A, Takaoka A, Superti-Furga G, Colinge J, Ludewig B, Löhning M, Bergthaler A. Bhattacharya A, et al. Among authors: merkler d. Immunity. 2015 Nov 17;43(5):974-86. doi: 10.1016/j.immuni.2015.10.013. Immunity. 2015. PMID: 26588782 Free PMC article.
Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner.
Datta M, Staszewski O, Raschi E, Frosch M, Hagemeyer N, Tay TL, Blank T, Kreutzfeldt M, Merkler D, Ziegler-Waldkirch S, Matthias P, Meyer-Luehmann M, Prinz M. Datta M, et al. Among authors: merkler d. Immunity. 2018 Mar 20;48(3):514-529.e6. doi: 10.1016/j.immuni.2018.02.016. Epub 2018 Mar 13. Immunity. 2018. PMID: 29548672 Free article.
Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.
Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T. Knier B, et al. Among authors: merkler d. Nat Immunol. 2018 Dec;19(12):1341-1351. doi: 10.1038/s41590-018-0237-5. Epub 2018 Oct 29. Nat Immunol. 2018. PMID: 30374128 Free PMC article.
Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology.
Mohebiany AN, Ramphal NS, Karram K, Di Liberto G, Novkovic T, Klein M, Marini F, Kreutzfeldt M, Härtner F, Lacher SM, Bopp T, Mittmann T, Merkler D, Waisman A. Mohebiany AN, et al. Among authors: merkler d. Cell Rep. 2020 Feb 4;30(5):1585-1597.e6. doi: 10.1016/j.celrep.2019.12.097. Cell Rep. 2020. PMID: 32023471 Free article.
Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice.
Yermanos A, Neumeier D, Sandu I, Borsa M, Waindok AC, Merkler D, Oxenius A, Reddy ST. Yermanos A, et al. Among authors: merkler d. Proc Biol Sci. 2021 Feb 24;288(1945):20202793. doi: 10.1098/rspb.2020.2793. Epub 2021 Feb 24. Proc Biol Sci. 2021. PMID: 33622131 Free PMC article.
253 results