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Developing and implementing national health identifiers in resource limited countries: why, what, who, when and how?
Beck EJ, Shields JM, Tanna G, Henning G, de Vega I, Andrews G, Boucher P, Benting L, Garcia-Calleja JM, Cutler J, Ewing W, Kijsanayotin B, Kujinga T, Mahy M, Makofane K, Marsh K, Nacheeva C, Rangana N, Vega MFR, Sabin K, Varetska O, Macharia Wanyee S, Watiti S, Williams B, Zhao J, Nunez C, Ghys P, Low-Beer D. Beck EJ, et al. Among authors: ewing w. Glob Health Action. 2018;11(1):1440782. doi: 10.1080/16549716.2018.1440782. Glob Health Action. 2018. PMID: 29502484 Free PMC article.
Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition.
Corey L, Gilbert PB, Juraska M, Montefiori DC, Morris L, Karuna ST, Edupuganti S, Mgodi NM, deCamp AC, Rudnicki E, Huang Y, Gonzales P, Cabello R, Orrell C, Lama JR, Laher F, Lazarus EM, Sanchez J, Frank I, Hinojosa J, Sobieszczyk ME, Marshall KE, Mukwekwerere PG, Makhema J, Baden LR, Mullins JI, Williamson C, Hural J, McElrath MJ, Bentley C, Takuva S, Gomez Lorenzo MM, Burns DN, Espy N, Randhawa AK, Kochar N, Piwowar-Manning E, Donnell DJ, Sista N, Andrew P, Kublin JG, Gray G, Ledgerwood JE, Mascola JR, Cohen MS; HVTN 704/HPTN 085 and HVTN 703/HPTN 081 Study Teams. Corey L, et al. N Engl J Med. 2021 Mar 18;384(11):1003-1014. doi: 10.1056/NEJMoa2031738. N Engl J Med. 2021. PMID: 33730454 Free PMC article. Clinical Trial.
Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities.
Jurica EA, Wu X, Williams KN, Haque LE, Rampulla RA, Mathur A, Zhou M, Cao G, Cai H, Wang T, Liu H, Xu C, Kunselman LK, Antrilli TM, Hicks MB, Sun Q, Dierks EA, Apedo A, Moore DB, Foster KA, Cvijic ME, Panemangalore R, Khandelwal P, Wilkes JJ, Zinker BA, Robertson DG, Janovitz EB, Galella M, Li YX, Li J, Ramar T, Jalagam PR, Jayaram R, Whaley JM, Barrish JC, Robl JA, Ewing WR, Ellsworth BA. Jurica EA, et al. Among authors: ewing wr. Bioorg Med Chem. 2023 May 1;85:117273. doi: 10.1016/j.bmc.2023.117273. Epub 2023 Apr 4. Bioorg Med Chem. 2023. PMID: 37030194
Ligand Enabled Pd(II)-Catalyzed γ-C(sp3)-H Lactamization of Native Amides.
Liu S, Zhuang Z, Qiao JX, Yeung KS, Su S, Cherney EC, Ruan Z, Ewing WR, Poss MA, Yu JQ. Liu S, et al. Among authors: ewing wr. J Am Chem Soc. 2021 Dec 29;143(51):21657-21666. doi: 10.1021/jacs.1c10183. Epub 2021 Dec 16. J Am Chem Soc. 2021. PMID: 34914877 Free PMC article.
Milvexian, an orally bioavailable, small-molecule, reversible, direct inhibitor of factor XIa: In vitro studies and in vivo evaluation in experimental thrombosis in rabbits.
Wong PC, Crain EJ, Bozarth JM, Wu Y, Dilger AK, Wexler RR, Ewing WR, Gordon D, Luettgen JM. Wong PC, et al. Among authors: ewing wr. J Thromb Haemost. 2022 Feb;20(2):399-408. doi: 10.1111/jth.15588. Epub 2021 Nov 24. J Thromb Haemost. 2022. PMID: 34752670 Free PMC article. Clinical Trial.
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
Dilger AK, Pabbisetty KB, Corte JR, De Lucca I, Fang T, Yang W, Pinto DJP, Wang Y, Zhu Y, Mathur A, Li J, Hou X, Smith D, Sun D, Zhang H, Krishnananthan S, Wu DR, Myers JE Jr, Sheriff S, Rossi KA, Chacko S, Zheng JJ, Galella MA, Ziemba T, Dierks EA, Bozarth JM, Wu Y, Crain E, Wong PC, Luettgen JM, Wexler RR, Ewing WR. Dilger AK, et al. Among authors: ewing wr. J Med Chem. 2022 Feb 10;65(3):1770-1785. doi: 10.1021/acs.jmedchem.1c00613. Epub 2021 Sep 8. J Med Chem. 2022. PMID: 34494428
198 results