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Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.
Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K. Brookes DW, et al. Among authors: ayrton j. Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2. Br J Pharmacol. 2018. PMID: 29579332 Free PMC article.
Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice: Pulmonary PK-PD analysis of anti-fungal PC945.
Ito K, Kizawa Y, Kimura G, Nishimoto Y, Daly L, Knowles I, Hows M, Ayrton J, Strong P. Ito K, et al. Among authors: ayrton j. Eur J Pharm Sci. 2021 Aug 1;163:105878. doi: 10.1016/j.ejps.2021.105878. Epub 2021 May 18. Eur J Pharm Sci. 2021. PMID: 34015430 Free article.
A phase I and pharmacodynamic study of AT9283, a small-molecule inhibitor of aurora kinases in patients with relapsed/refractory leukemia or myelofibrosis.
Foran J, Ravandi F, Wierda W, Garcia-Manero G, Verstovsek S, Kadia T, Burger J, Yule M, Langford G, Lyons J, Ayrton J, Lock V, Borthakur G, Cortes J, Kantarjian H. Foran J, et al. Among authors: ayrton j. Clin Lymphoma Myeloma Leuk. 2014 Jun;14(3):223-30. doi: 10.1016/j.clml.2013.11.001. Epub 2013 Nov 14. Clin Lymphoma Myeloma Leuk. 2014. PMID: 24355079 Free PMC article. Clinical Trial.
37 results