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Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.
Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2.
Br J Pharmacol. 2018.
PMID: 29579332
Free PMC article.
Preclinical Characterization of PC786, an Inhaled Small-Molecule Respiratory Syncytial Virus L Protein Polymerase Inhibitor.
Coates M, Brookes D, Kim YI, Allen H, Fordyce EAF, Meals EA, Colley T, Ciana CL, Parra GF, Sherbukhin V, Stockwell JA, Thomas JC, Hunt SF, Anderson-Dring L, Onions ST, Cass L, Murray PJ, Ito K, Strong P, DeVincenzo JP, Rapeport G.
Coates M, et al.
Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00737-17. doi: 10.1128/AAC.00737-17. Print 2017 Sep.
Antimicrob Agents Chemother. 2017.
PMID: 28652242
Free PMC article.
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Discovery of novel benzothienoazepine derivatives as potent inhibitors of respiratory syncytial virus.
Fordyce EAF, Brookes DW, Lise-Ciana C, Coates MS, Hunt SF, Ito K, King-Underwood J, Onions ST, Parra GF, Rapeport G, Sherbukhin V, Stockwell JA, Strong P, Thomas JC, Murray J.
Fordyce EAF, et al. Among authors: brookes dw.
Bioorg Med Chem Lett. 2017 May 15;27(10):2201-2206. doi: 10.1016/j.bmcl.2017.03.053. Epub 2017 Mar 23.
Bioorg Med Chem Lett. 2017.
PMID: 28372911
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Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness.
Brookes DW, Miah S, Lackenby A, Hartgroves L, Barclay WS.
Brookes DW, et al.
J Antimicrob Chemother. 2011 Mar;66(3):466-70. doi: 10.1093/jac/dkq486. Epub 2010 Dec 16.
J Antimicrob Chemother. 2011.
PMID: 21172786
Free PMC article.
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Quality assurance--a study in radiography.
Brookes D, Greenwood E, Moxon L.
Brookes D, et al.
Radiogr Today. 1991 Jun;57(649):13-5.
Radiogr Today. 1991.
PMID: 1910515
No abstract available.
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