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Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium.
Brookes DW, Coates M, Allen H, Daly L, Constant S, Huang S, Hows M, Davis A, Cass L, Ayrton J, Knowles I, Strong P, Rapeport G, Ito K. Brookes DW, et al. Among authors: knowles i. Br J Pharmacol. 2018 Jun;175(12):2520-2534. doi: 10.1111/bph.14221. Epub 2018 May 2. Br J Pharmacol. 2018. PMID: 29579332 Free PMC article.
Relationship between anti-fungal effects and lung exposure of PC945, a novel inhaled antifungal agent, in Aspergillus fumigatus infected mice: Pulmonary PK-PD analysis of anti-fungal PC945.
Ito K, Kizawa Y, Kimura G, Nishimoto Y, Daly L, Knowles I, Hows M, Ayrton J, Strong P. Ito K, et al. Among authors: knowles i. Eur J Pharm Sci. 2021 Aug 1;163:105878. doi: 10.1016/j.ejps.2021.105878. Epub 2021 May 18. Eur J Pharm Sci. 2021. PMID: 34015430 Free article.
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Onions ST, Ito K, Charron CE, Brown RJ, Colucci M, Frickel F, Hardy G, Joly K, King-Underwood J, Kizawa Y, Knowles I, Murray PJ, Novak A, Rani A, Rapeport G, Smith A, Strong P, Taddei DM, Williams JG. Onions ST, et al. Among authors: knowles i. J Med Chem. 2016 Mar 10;59(5):1727-46. doi: 10.1021/acs.jmedchem.5b01029. Epub 2016 Feb 4. J Med Chem. 2016. PMID: 26800309
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators. Salloway S, et al. N Engl J Med. 2014 Jan 23;370(4):322-33. doi: 10.1056/NEJMoa1304839. N Engl J Med. 2014. PMID: 24450891 Free PMC article. Clinical Trial.
Dual bronchodilatory and pulmonary anti-inflammatory activity of RO5024118, a novel agonist at vasoactive intestinal peptide VPAC2 receptors.
Tannu SA, Renzetti LM, Tare N, Ventre JD, Lavelle D, Lin TA, Morschauser A, Paciorek J, Bolin DR, Michel H, Singer L, Hargaden M, Knowles I, Gardiner P, Cazzola M, Calzetta L, Matera MG, Hicks A. Tannu SA, et al. Among authors: knowles i. Br J Pharmacol. 2010 Nov;161(6):1329-42. doi: 10.1111/j.1476-5381.2010.00975.x. Br J Pharmacol. 2010. PMID: 20735404 Free PMC article.
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