Bedbrook CN - Search Results

1

Learned protein embeddings for machine learning.

Yang KK, Wu Z, Bedbrook CN, Arnold FH. Yang KK, et al. Among authors: bedbrook cn. Bioinformatics. 2018 Aug 1;34(15):2642-2648. doi: 10.1093/bioinformatics/bty178. Bioinformatics. 2018. PMID: 29584811 Free PMC article.

2

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

Bedbrook CN, Yang KK, Rice AJ, Gradinaru V, Arnold FH. Bedbrook CN, et al. PLoS Comput Biol. 2017 Oct 23;13(10):e1005786. doi: 10.1371/journal.pcbi.1005786. eCollection 2017 Oct. PLoS Comput Biol. 2017. PMID: 29059183 Free PMC article.

3

Learned protein embeddings for machine learning.

Yang KK, Wu Z, Bedbrook CN, Arnold FH. Yang KK, et al. Among authors: bedbrook cn. Bioinformatics. 2018 Dec 1;34(23):4138. doi: 10.1093/bioinformatics/bty455. Bioinformatics. 2018. PMID: 29933431 Free PMC article. No abstract available.

4

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics.

Bedbrook CN, Yang KK, Robinson JE, Mackey ED, Gradinaru V, Arnold FH. Bedbrook CN, et al. Nat Methods. 2019 Nov;16(11):1176-1184. doi: 10.1038/s41592-019-0583-8. Epub 2019 Oct 14. Nat Methods. 2019. PMID: 31611694 Free PMC article.

5

Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination.

Smith MA, Bedbrook CN, Wu T, Arnold FH. Smith MA, et al. Among authors: bedbrook cn. ACS Synth Biol. 2013 Dec 20;2(12):690-6. doi: 10.1021/sb400010m. Epub 2013 Jun 3. ACS Synth Biol. 2013. PMID: 23688124

6

Recent advances in engineering microbial rhodopsins for optogenetics.

McIsaac RS, Bedbrook CN, Arnold FH. McIsaac RS, et al. Among authors: bedbrook cn. Curr Opin Struct Biol. 2015 Aug;33:8-15. doi: 10.1016/j.sbi.2015.05.001. Epub 2015 Jun 1. Curr Opin Struct Biol. 2015. PMID: 26038227 Free PMC article. Review.

7

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo.

Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Bedbrook CN, et al. Chem Biol. 2015 Aug 20;22(8):1108-21. doi: 10.1016/j.chembiol.2015.06.020. Epub 2015 Jul 23. Chem Biol. 2015. PMID: 26211362 Free PMC article.

8

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins.

Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Bedbrook CN, et al. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2624-E2633. doi: 10.1073/pnas.1700269114. Epub 2017 Mar 10. Proc Natl Acad Sci U S A. 2017. PMID: 28283661 Free PMC article.

9

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons.

Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V. Flytzanis NC, et al. Among authors: bedbrook cn. Nat Commun. 2014 Sep 15;5:4894. doi: 10.1038/ncomms5894. Nat Commun. 2014. PMID: 25222271 Free PMC article.

10

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JKB, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Herwig L, et al. Among authors: bedbrook cn. Cell Chem Biol. 2017 Mar 16;24(3):415-425. doi: 10.1016/j.chembiol.2017.02.008. Epub 2017 Mar 2. Cell Chem Biol. 2017. PMID: 28262559 Free PMC article.

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