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Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial.
Maertens JA, Raad II, Marr KA, Patterson TF, Kontoyiannis DP, Cornely OA, Bow EJ, Rahav G, Neofytos D, Aoun M, Baddley JW, Giladi M, Heinz WJ, Herbrecht R, Hope W, Karthaus M, Lee DG, Lortholary O, Morrison VA, Oren I, Selleslag D, Shoham S, Thompson GR 3rd, Lee M, Maher RM, Schmitt-Hoffmann AH, Zeiher B, Ullmann AJ. Maertens JA, et al. Among authors: schmitt hoffmann ah. Lancet. 2016 Feb 20;387(10020):760-9. doi: 10.1016/S0140-6736(15)01159-9. Epub 2015 Dec 10. Lancet. 2016. PMID: 26684607 Clinical Trial.
Isavuconazole for treatment of rare invasive fungal diseases.
Cornely OA, Mullane KM, Ostrosky-Zeichner L, Maher RM, Croos-Dabrera R, Lu Q, Lademacher C, Perfect JR, Oren I, Schmitt-Hoffmann AH, Giladi M, Marty FM, Rahav G. Cornely OA, et al. Among authors: schmitt hoffmann ah. Mycoses. 2018 Aug;61(8):518-533. doi: 10.1111/myc.12778. Mycoses. 2018. PMID: 29611246 Clinical Trial.
Effect of mild and moderate liver disease on the pharmacokinetics of isavuconazole after intravenous and oral administration of a single dose of the prodrug BAL8557.
Schmitt-Hoffmann A, Roos B, Spickermann J, Heep M, Peterfaí E, Edwards DJ, Stoeckel K. Schmitt-Hoffmann A, et al. Antimicrob Agents Chemother. 2009 Nov;53(11):4885-90. doi: 10.1128/AAC.00319-09. Epub 2009 Aug 10. Antimicrob Agents Chemother. 2009. PMID: 19667286 Free PMC article. Clinical Trial.
Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.
Paech F, Messner S, Spickermann J, Wind M, Schmitt-Hoffmann AH, Witschi AT, Howell BA, Church RJ, Woodhead J, Engelhardt M, Krähenbühl S, Maurer M. Paech F, et al. Among authors: schmitt hoffmann ah. Arch Toxicol. 2017 Nov;91(11):3647-3662. doi: 10.1007/s00204-017-1994-x. Epub 2017 May 23. Arch Toxicol. 2017. PMID: 28536862 Clinical Trial.
Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Woodhead JL, Paech F, Maurer M, Engelhardt M, Schmitt-Hoffmann AH, Spickermann J, Messner S, Wind M, Witschi AT, Krähenbühl S, Siler SQ, Watkins PB, Howell BA. Woodhead JL, et al. Among authors: schmitt hoffmann ah. Clin Transl Sci. 2018 Sep;11(5):498-505. doi: 10.1111/cts.12560. Epub 2018 Jun 7. Clin Transl Sci. 2018. PMID: 29877622 Free PMC article.
A phase 2, randomized, double-blind, multicenter trial to evaluate the safety and efficacy of three dosing regimens of isavuconazole compared with fluconazole in patients with uncomplicated esophageal candidiasis.
Viljoen J, Azie N, Schmitt-Hoffmann AH, Ghannoum M. Viljoen J, et al. Among authors: schmitt hoffmann ah. Antimicrob Agents Chemother. 2015 Mar;59(3):1671-9. doi: 10.1128/AAC.04586-14. Epub 2015 Jan 5. Antimicrob Agents Chemother. 2015. PMID: 25561337 Free PMC article. Clinical Trial.
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