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591 results

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Page 1
Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).
Welte T, Dellinger RP, Ebelt H, Ferrer M, Opal SM, Singer M, Vincent JL, Werdan K, Martin-Loeches I, Almirall J, Artigas A, Ignacio Ayestarán J, Nuding S, Ferrer R, Sirgo Rodríguez G, Shankar-Hari M, Álvarez-Lerma F, Riessen R, Sirvent JM, Kluge S, Zacharowski K, Bonastre Mora J, Lapp H, Wöbker G, Achtzehn U, Brealey D, Kempa A, Sánchez García M, Brederlau J, Kochanek M, Reschreiter HP, Wise MP, Belohradsky BH, Bobenhausen I, Dälken B, Dubovy P, Langohr P, Mayer M, Schüttrumpf J, Wartenberg-Demand A, Wippermann U, Wolf D, Torres A. Welte T, et al. Among authors: zacharowski k. Intensive Care Med. 2018 Apr;44(4):438-448. doi: 10.1007/s00134-018-5143-7. Epub 2018 Apr 9. Intensive Care Med. 2018. PMID: 29632995 Free PMC article. Clinical Trial.
Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections.
Vincent JL, Brealey D, Libert N, Abidi NE, O'Dwyer M, Zacharowski K, Mikaszewska-Sokolewicz M, Schrenzel J, Simon F, Wilks M, Picard-Maureau M, Chalfin DB, Ecker DJ, Sampath R, Singer M; Rapid Diagnosis of Infections in the Critically Ill Team. Vincent JL, et al. Among authors: zacharowski k. Crit Care Med. 2015 Nov;43(11):2283-91. doi: 10.1097/CCM.0000000000001249. Crit Care Med. 2015. PMID: 26327198 Free PMC article.
The detection of microbial DNA but not cultured bacteria is associated with increased mortality in patients with suspected sepsis-a prospective multi-centre European observational study.
O'Dwyer MJ, Starczewska MH, Schrenzel J, Zacharowski K, Ecker DJ, Sampath R, Brealey D, Singer M, Libert N, Wilks M, Vincent JL. O'Dwyer MJ, et al. Among authors: zacharowski k. Clin Microbiol Infect. 2017 Mar;23(3):208.e1-208.e6. doi: 10.1016/j.cmi.2016.11.010. Epub 2016 Nov 23. Clin Microbiol Infect. 2017. PMID: 27890455 Free article.
Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study.
Hoste E, Bihorac A, Al-Khafaji A, Ortega LM, Ostermann M, Haase M, Zacharowski K, Wunderink R, Heung M, Lissauer M, Self WH, Koyner JL, Honore PM, Prowle JR, Joannidis M, Forni LG, Kampf JP, McPherson P, Kellum JA, Chawla LS; RUBY Investigators. Hoste E, et al. Among authors: zacharowski k. Intensive Care Med. 2020 May;46(5):943-953. doi: 10.1007/s00134-019-05919-0. Epub 2020 Feb 6. Intensive Care Med. 2020. PMID: 32025755 Free PMC article.
Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.
Molinari L, Heskia F, Peerapornratana S, Ronco C, Guzzi L, Toback S, Birch R, Beyhaghi H, Kwan T, Kampf JP, Yealy DM, Kellum JA; Sapphire and Protocolized Care for Early Septic Shock (ProCESS) Investigators. Molinari L, et al. Crit Care Med. 2021 Oct 1;49(10):1706-1716. doi: 10.1097/CCM.0000000000005061. Crit Care Med. 2021. PMID: 33927121 Free PMC article.
Do ventilatory parameters influence outcome in patients with severe acute respiratory infection? Secondary analysis of an international, multicentre14-day inception cohort study.
Sakr Y, Midega T, Antoniazzi J, Solé-Violán J, Bauer PR, Ostermann M, Pellis T, Szakmany T, Zacharowski K, Ñamendys-Silva SA, Pham T, Ferrer R, Taccone FS, van Haren F, Brochard L; IC-GLOSSARI investigators and the ESICM Trials group. Sakr Y, et al. Among authors: zacharowski k. J Crit Care. 2021 Dec;66:78-85. doi: 10.1016/j.jcrc.2021.08.008. Epub 2021 Aug 27. J Crit Care. 2021. PMID: 34461380 Free PMC article.
(1 → 3)-β-D-Glucan-guided antifungal therapy in adults with sepsis: the CandiSep randomized clinical trial.
Bloos F, Held J, Kluge S, Simon P, Kogelmann K, de Heer G, Kuhn SO, Jarczak D, Motsch J, Hempel G, Weiler N, Weyland A, Drüner M, Gründling M, Meybohm P, Richter D, Jaschinski U, Moerer O, Günther U, Schädler D, Weiss R, Putensen C, Castellanos I, Kurzai O, Schlattmann P, Cornely OA, Bauer M, Thomas-Rüddel D; SepNet Study Group. Bloos F, et al. Intensive Care Med. 2022 Jul;48(7):865-875. doi: 10.1007/s00134-022-06733-x. Epub 2022 Jun 16. Intensive Care Med. 2022. PMID: 35708758 Free PMC article. Clinical Trial.
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study.
Rahmel T, Kraft F, Haberl H, Achtzehn U, Brandenburger T, Neb H, Jarczak D, Dietrich M, Magunia H, Zimmer F, Basten J, Landgraf C, Koch T, Zacharowski K, Weigand MA, Rosenberger P, Ullrich R, Meybohm P, Nierhaus A, Kindgen-Milles D, Timmesfeld N, Adamzik M. Rahmel T, et al. Among authors: zacharowski k. Crit Care. 2022 Jul 7;26(1):204. doi: 10.1186/s13054-022-04059-0. Crit Care. 2022. PMID: 35799196 Free PMC article.
Presymptomatic diagnosis of postoperative infection and sepsis using gene expression signatures.
Lukaszewski RA, Jones HE, Gersuk VH, Russell P, Simpson A, Brealey D, Walker J, Thomas M, Whitehouse T, Ostermann M, Koch A, Zacharowski K, Kruhoffer M, Chaussabel D, Singer M. Lukaszewski RA, et al. Among authors: zacharowski k. Intensive Care Med. 2022 Sep;48(9):1133-1143. doi: 10.1007/s00134-022-06769-z. Epub 2022 Jul 13. Intensive Care Med. 2022. PMID: 35831640 Free PMC article.
The fibrin-derived peptide Bbeta15-42 is cardioprotective in a pig model of myocardial ischemia-reperfusion injury.
Roesner JP, Petzelbauer P, Koch A, Mersmann J, Zacharowski PA, Boehm O, Reingruber S, Pasteiner W, Mascher D, Wolzt M, Barthuber C, Nöldge-Schomburg GE, Scheeren TW, Zacharowski K. Roesner JP, et al. Among authors: zacharowski k, zacharowski pa. Crit Care Med. 2007 Jul;35(7):1730-5. doi: 10.1097/01.CCM.0000269035.30231.76. Crit Care Med. 2007. PMID: 17522584 Clinical Trial.
591 results