Enzymes of the purinergic signaling system exhibit diverse effects on the degeneration of valvular interstitial cells in a 3-D microenvironment.
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FASEB J. 2018 Aug;32(8):4356-4369. doi: 10.1096/fj.201701326R. Epub 2018 Mar 20.
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PMID: 29558203
Increasing adenosine levels, as well as stimulating the adenosine receptors A(2A) and A(2B), exhibited strong prodegenerative effects, whereas conversely, lowering adenosine levels by inhibition of CD73 resulted in protective effects against degeneration. ...Stimula …
Increasing adenosine levels, as well as stimulating the adenosine receptors A(2A) and A(2B), exhibited strong prodegenerative …