Varnäs K - Search Results

1

The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.

Durant ST, Zheng L, Wang Y, Chen K, Zhang L, Zhang T, Yang Z, Riches L, Trinidad AG, Fok JHL, Hunt T, Pike KG, Wilson J, Smith A, Colclough N, Reddy VP, Sykes A, Janefeldt A, Johnström P, Varnäs K, Takano A, Ling S, Orme J, Stott J, Roberts C, Barrett I, Jones G, Roudier M, Pierce A, Allen J, Kahn J, Sule A, Karlin J, Cronin A, Chapman M, Valerie K, Illingworth R, Pass M. Durant ST, et al. Among authors: varnas k. Sci Adv. 2018 Jun 20;4(6):eaat1719. doi: 10.1126/sciadv.aat1719. eCollection 2018 Jun. Sci Adv. 2018. PMID: 29938225 Free PMC article.

2

Quantitative analysis of [11C]AZ10419369 binding to 5-HT1B receptors in human brain.

Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L. Varnäs K, et al. J Cereb Blood Flow Metab. 2011 Jan;31(1):113-23. doi: 10.1038/jcbfm.2010.55. Epub 2010 Apr 28. J Cereb Blood Flow Metab. 2011. PMID: 20424633 Free PMC article.

3

Synthesis, radiolabeling, and in vivo pharmacokinetic evaluation of the amyloid beta radioligand [11C]AZD4694 in nonhuman primates.

Schou M, Varnäs K, Sandell J, Johnström P, Cselenyi Z, Svensson S, Nakao R, Amini N, Bergman L, Sumic A, Gulyas B, Lindström-Böö E, Halldin C, Farde L. Schou M, et al. Among authors: varnas k. Mol Imaging Biol. 2014 Apr;16(2):173-9. doi: 10.1007/s11307-013-0666-3. Mol Imaging Biol. 2014. PMID: 24002613

4

Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: a PET study.

Takano A, Gulyás B, Varnäs K, Little PB, Noerregaard PK, Jensen NO, Elling CE, Halldin C. Takano A, et al. Among authors: varnas k. Synapse. 2014 Mar;68(3):89-97. doi: 10.1002/syn.21721. Epub 2013 Dec 2. Synapse. 2014. PMID: 24293119

5

Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing.

Johnström P, Bergman L, Varnäs K, Malmquist J, Halldin C, Farde L. Johnström P, et al. Among authors: varnas k. Nucl Med Biol. 2015 Jun;42(6):555-60. doi: 10.1016/j.nucmedbio.2015.02.001. Epub 2015 Feb 8. Nucl Med Biol. 2015. PMID: 25726760

6

A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates.

Hjorth S, Karlsson C, Jucaite A, Varnäs K, Wählby Hamrén U, Johnström P, Gulyás B, Donohue SR, Pike VW, Halldin C, Farde L. Hjorth S, et al. Among authors: varnas k. Neuropharmacology. 2016 Feb;101:519-30. doi: 10.1016/j.neuropharm.2015.03.002. Epub 2015 Mar 17. Neuropharmacology. 2016. PMID: 25791528 Free PMC article.

7

Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates.

Schou M, Varnäs K, Lundquist S, Nakao R, Amini N, Takano A, Finnema SJ, Halldin C, Farde L. Schou M, et al. Among authors: varnas k. Int J Neuropsychopharmacol. 2015 Mar 26;18(10):pyv036. doi: 10.1093/ijnp/pyv036. Int J Neuropsychopharmacol. 2015. PMID: 25813017 Free PMC article.

8

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease.

Jucaite A, Svenningsson P, Rinne JO, Cselényi Z, Varnäs K, Johnström P, Amini N, Kirjavainen A, Helin S, Minkwitz M, Kugler AR, Posener JA, Budd S, Halldin C, Varrone A, Farde L. Jucaite A, et al. Among authors: varnas k. Brain. 2015 Sep;138(Pt 9):2687-700. doi: 10.1093/brain/awv184. Epub 2015 Jul 1. Brain. 2015. PMID: 26137956 Clinical Trial.

9

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.

Zeng Q, Wang J, Cheng Z, Chen K, Johnström P, Varnäs K, Li DY, Yang ZF, Zhang X. Zeng Q, et al. Among authors: varnas k. J Med Chem. 2015 Oct 22;58(20):8200-15. doi: 10.1021/acs.jmedchem.5b01073. Epub 2015 Oct 9. J Med Chem. 2015. PMID: 26313252

10

Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor.

Schou M, Varnäs K, Jureus A, Ahlgren C, Malmquist J, Häggkvist J, Tari L, Wesolowski SS, Throner SR, Brown DG, Nilsson M, Johnström P, Finnema SJ, Nakao R, Amini N, Takano A, Farde L. Schou M, et al. Among authors: varnas k. ACS Chem Neurosci. 2016 Feb 17;7(2):177-84. doi: 10.1021/acschemneuro.5b00268. Epub 2015 Nov 30. ACS Chem Neurosci. 2016. PMID: 26529287

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