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Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: pirtskhalava t. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
Adipogenesis and aging: does aging make fat go MAD?
Kirkland JL, Tchkonia T, Pirtskhalava T, Han J, Karagiannides I. Kirkland JL, et al. Among authors: pirtskhalava t. Exp Gerontol. 2002 Jun;37(6):757-67. doi: 10.1016/s0531-5565(02)00014-1. Exp Gerontol. 2002. PMID: 12175476 Review.
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
Tchkonia T, Tchoukalova YD, Giorgadze N, Pirtskhalava T, Karagiannides I, Forse RA, Koo A, Stevenson M, Chinnappan D, Cartwright A, Jensen MD, Kirkland JL. Tchkonia T, et al. Among authors: pirtskhalava t. Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E267-77. doi: 10.1152/ajpendo.00265.2004. Epub 2004 Sep 21. Am J Physiol Endocrinol Metab. 2005. PMID: 15383371 Free article.
Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis.
Tchkonia T, Pirtskhalava T, Thomou T, Cartwright MJ, Wise B, Karagiannides I, Shpilman A, Lash TL, Becherer JD, Kirkland JL. Tchkonia T, et al. Among authors: pirtskhalava t. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1810-9. doi: 10.1152/ajpendo.00295.2007. Epub 2007 Oct 2. Am J Physiol Endocrinol Metab. 2007. PMID: 17911345 Free article.
Aging, depot origin, and preadipocyte gene expression.
Cartwright MJ, Schlauch K, Lenburg ME, Tchkonia T, Pirtskhalava T, Cartwright A, Thomou T, Kirkland JL. Cartwright MJ, et al. Among authors: pirtskhalava t. J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):242-51. doi: 10.1093/gerona/glp213. Epub 2010 Jan 27. J Gerontol A Biol Sci Med Sci. 2010. PMID: 20106964 Free PMC article.
Deleted in Breast Cancer 1 regulates cellular senescence during obesity.
Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Escande C, et al. Among authors: pirtskhalava t. Aging Cell. 2014 Oct;13(5):951-3. doi: 10.1111/acel.12235. Epub 2014 Jul 3. Aging Cell. 2014. PMID: 24992635 Free PMC article.
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.
Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL. Stout MB, et al. Among authors: pirtskhalava t. Aging (Albany NY). 2014 Jul;6(7):575-86. doi: 10.18632/aging.100681. Aging (Albany NY). 2014. PMID: 25063774 Free PMC article.
TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.
Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. Idrissova L, et al. Among authors: pirtskhalava t. J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033. Epub 2014 Nov 28. J Hepatol. 2015. PMID: 25445398 Free PMC article.
57 results