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Respiratory syncytial virus induces phosphorylation of mTOR at ser2448 in CD8 T cells from nasal washes of infected infants.
de Souza AP, de Freitas DN, Antuntes Fernandes KE, D'Avila da Cunha M, Antunes Fernandes JL, Benetti Gassen R, Fazolo T, Pinto LA, Scotta M, Mattiello R, Pitrez PM, Bonorino C, Stein RT. de Souza AP, et al. Among authors: fazolo t. Clin Exp Immunol. 2016 Feb;183(2):248-57. doi: 10.1111/cei.12720. Epub 2015 Nov 24. Clin Exp Immunol. 2016. PMID: 26437614 Free PMC article.
IL-21 treatment recovers follicular helper T cells and neutralizing antibody production in respiratory syncytial virus infection.
Gassen RB, Fazolo T, Nascimento de Freitas D, Borges TJ, Lima K, Antunes GL, Maito F, Bueno Mendes DA, Báfica A, Rodrigues LC Jr, Stein R, Duarte de Souza AP, Bonorino C. Gassen RB, et al. Among authors: fazolo t. Immunol Cell Biol. 2021 Mar;99(3):309-322. doi: 10.1111/imcb.12418. Epub 2020 Dec 4. Immunol Cell Biol. 2021. PMID: 33068449
RvD1 treatment during primary infection modulates memory response increasing viral load during respiratory viral reinfection.
de Freitas DDN, Marinho Franceschina C, Muller D, Hilario GT, Gassen RB, Fazolo T, de Lima Kaminski V, Bogo Chies JA, Maito F, Antunes KH, Zanin RF, Rodrigues LC Jr, Duarte de Souza AP. de Freitas DDN, et al. Among authors: fazolo t. Immunobiology. 2021 Nov;226(6):152151. doi: 10.1016/j.imbio.2021.152151. Epub 2021 Oct 31. Immunobiology. 2021. PMID: 34742024
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses.
Fazolo T, Lima K, Fontoura JC, de Souza PO, Hilario G, Zorzetto R, Júnior LR, Pscheidt VM, de Castilhos Ferreira Neto J, Haubert AF, Gambin I, Oliveira AC, Mello RS, de Bastos Balbe E Gutierres M, Gassen RB, Coimbra LD, Borin A, Marques RE, Sartor ITS, Zavaglia GO, Fernandes IR, Nakaya HI, Varela FH, Polese-Bonatto M, Borges TJ, Callegari-Jacques SM, da Costa MSC, de Araujo Schwartz J, Scotta MC, Stein RT, Bonorino C. Fazolo T, et al. Nat Commun. 2021 Nov 25;12(1):6844. doi: 10.1038/s41467-021-27120-y. Nat Commun. 2021. PMID: 34824230 Free PMC article.
SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies.
Lima K, Fontoura JC, de Souza PO, Fazolo T, Hilario G, Zorzetto R, Rodrigues Junior LC, Coimbra LD, Borin A, Bispo-Dos-Santos K, Granja F, Marques RE, Zavaglia GO, Fernandes IR, Varela FH, Polese-Bonatto M, Tonini ML, Ikeda do Carmo GM, de Almeida WAF, Borges TJ, Nakaya HI, Proenca-Modena JL, Callegari-Jacques SM, Scotta MC, Stein RT, Bonorino C. Lima K, et al. Among authors: fazolo t. Front Immunol. 2022 Nov 2;13:1033364. doi: 10.3389/fimmu.2022.1033364. eCollection 2022. Front Immunol. 2022. PMID: 36405692 Free PMC article.
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