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Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease.
Kontzias A, Kotlyar A, Laurence A, Changelian P, O'Shea JJ. Kontzias A, et al. Among authors: changelian p. Curr Opin Pharmacol. 2012 Aug;12(4):464-70. doi: 10.1016/j.coph.2012.06.008. Epub 2012 Jul 19. Curr Opin Pharmacol. 2012. PMID: 22819198 Free PMC article. Review.
Translating JAKs to Jakinibs.
Gadina M, Chisolm DA, Philips RL, McInness IB, Changelian PS, O'Shea JJ. Gadina M, et al. Among authors: changelian ps. J Immunol. 2020 Apr 15;204(8):2011-2020. doi: 10.4049/jimmunol.1901477. J Immunol. 2020. PMID: 32253269 Review.
Jak3 and the pathogenesis of severe combined immunodeficiency.
O'Shea JJ, Husa M, Li D, Hofmann SR, Watford W, Roberts JL, Buckley RH, Changelian P, Candotti F. O'Shea JJ, et al. Among authors: changelian p. Mol Immunol. 2004 Jul;41(6-7):727-37. doi: 10.1016/j.molimm.2004.04.014. Mol Immunol. 2004. PMID: 15220007 Review.
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
Zhou YJ, Magnuson KS, Cheng TP, Gadina M, Frucht DM, Galon J, Candotti F, Geahlen RL, Changelian PS, O'Shea JJ. Zhou YJ, et al. Among authors: changelian ps. Mol Cell Biol. 2000 Jun;20(12):4371-80. doi: 10.1128/MCB.20.12.4371-4380.2000. Mol Cell Biol. 2000. PMID: 10825200 Free PMC article.
The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.
Chen M, Cheng A, Chen YQ, Hymel A, Hanson EP, Kimmel L, Minami Y, Taniguchi T, Changelian PS, O'Shea JJ. Chen M, et al. Among authors: changelian ps. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6910-5. doi: 10.1073/pnas.94.13.6910. Proc Natl Acad Sci U S A. 1997. PMID: 9192665 Free PMC article.
42 results