Rudolph U - Search Results

1

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABA_A receptors.

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU. Ralvenius WT, et al. Among authors: rudolph u. Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0. Nat Commun. 2018. PMID: 30104684 Free PMC article.

2

Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype.

Ralvenius WT, Benke D, Acuña MA, Rudolph U, Zeilhofer HU. Ralvenius WT, et al. Among authors: rudolph u. Nat Commun. 2015 Apr 13;6:6803. doi: 10.1038/ncomms7803. Nat Commun. 2015. PMID: 25865415 Free PMC article.

3

Reversal of pathological pain through specific spinal GABAA receptor subtypes.

Knabl J, Witschi R, Hösl K, Reinold H, Zeilhofer UB, Ahmadi S, Brockhaus J, Sergejeva M, Hess A, Brune K, Fritschy JM, Rudolph U, Möhler H, Zeilhofer HU. Knabl J, et al. Among authors: rudolph u. Nature. 2008 Jan 17;451(7176):330-4. doi: 10.1038/nature06493. Nature. 2008. PMID: 18202657

4

Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites.

Paul J, Yévenes GE, Benke D, Di Lio A, Ralvenius WT, Witschi R, Scheurer L, Cook JM, Rudolph U, Fritschy JM, Zeilhofer HU. Paul J, et al. Among authors: rudolph u. Neuropsychopharmacology. 2014 Jan;39(2):477-87. doi: 10.1038/npp.2013.221. Epub 2013 Aug 28. Neuropsychopharmacology. 2014. PMID: 24045508 Free PMC article.

5

A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.

Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson AJ, Yee BK, Zeilhofer HU, Engin E, Rudolph U. Behlke LM, et al. Among authors: rudolph u. Neuropsychopharmacology. 2016 Sep;41(10):2492-501. doi: 10.1038/npp.2016.49. Epub 2016 Apr 12. Neuropsychopharmacology. 2016. PMID: 27067130 Free PMC article.

6

The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia.

Ralvenius WT, Acuña MA, Benke D, Matthey A, Daali Y, Rudolph U, Desmeules J, Zeilhofer HU, Besson M. Ralvenius WT, et al. Among authors: rudolph u. Neuropharmacology. 2016 Oct;109:366-375. doi: 10.1016/j.neuropharm.2016.07.004. Epub 2016 Jul 5. Neuropharmacology. 2016. PMID: 27392635 Free PMC article.

7

TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA_A receptors.

Neumann E, Ralvenius WT, Acuña MA, Rudolph U, Zeilhofer HU. Neumann E, et al. Among authors: rudolph u. Neuropharmacology. 2018 Dec;143:71-78. doi: 10.1016/j.neuropharm.2018.09.026. Epub 2018 Sep 18. Neuropharmacology. 2018. PMID: 30240781

8

Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.

Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU. Knabl J, et al. Among authors: rudolph u. Pain. 2009 Feb;141(3):233-238. doi: 10.1016/j.pain.2008.10.015. Epub 2008 Dec 16. Pain. 2009. PMID: 19091469

9

Presynaptic alpha2-GABAA receptors in primary afferent depolarization and spinal pain control.

Witschi R, Punnakkal P, Paul J, Walczak JS, Cervero F, Fritschy JM, Kuner R, Keist R, Rudolph U, Zeilhofer HU. Witschi R, et al. Among authors: rudolph u. J Neurosci. 2011 Jun 1;31(22):8134-42. doi: 10.1523/JNEUROSCI.6328-10.2011. J Neurosci. 2011. PMID: 21632935 Free PMC article.

10

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

Rudolph U, Crestani F, Benke D, Brünig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Möhler H. Rudolph U, et al. Nature. 1999 Oct 21;401(6755):796-800. doi: 10.1038/44579. Nature. 1999. PMID: 10548105

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