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Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition.
Silva G, Marins M, Chaichanasak N, Yoon Y, Fachin AL, Pinhanelli VC, Regasini LO, Dos Santos MB, Ayusso GM, Marques BC, Wu WW, Phue JN, Shen RF, Baek SJ. Silva G, et al. Among authors: regasini lo. PLoS One. 2018 Aug 17;13(8):e0202263. doi: 10.1371/journal.pone.0202263. eCollection 2018. PLoS One. 2018. PMID: 30118500 Free PMC article.
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei.
Francisco KR, Monti L, Yang W, Park H, Liu LJ, Watkins K, Amarasinghe DK, Nalli M, Roberto Polaquini C, Regasini LO, Eduardo Miller Crotti A, Silvestri R, Guidi Magalhães L, Caffrey CR. Francisco KR, et al. Among authors: regasini lo. Bioorg Med Chem Lett. 2023 Feb 1;81:129123. doi: 10.1016/j.bmcl.2023.129123. Epub 2023 Jan 3. Bioorg Med Chem Lett. 2023. PMID: 36608774 Free PMC article.
Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Passalacqua TG, Dutra LA, de Almeida L, Velásquez AM, Torres FA, Yamasaki PR, dos Santos MB, Regasini LO, Michels PA, Bolzani Vda S, Graminha MA. Passalacqua TG, et al. Among authors: regasini lo. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3342-5. doi: 10.1016/j.bmcl.2015.05.072. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26055530
The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species.
Passalacqua TG, Torres FA, Nogueira CT, de Almeida L, Del Cistia ML, dos Santos MB, Dutra LA, Bolzani VS, Regasini LO, Graminha MA, Marchetto R, Zottis A. Passalacqua TG, et al. Among authors: regasini lo. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3564-8. doi: 10.1016/j.bmcl.2015.06.085. Epub 2015 Jun 30. Bioorg Med Chem Lett. 2015. PMID: 26169126
Activity of 3'-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models.
Palanco AC, Lacorte Singulani J, Costa-Orlandi CB, Gullo FP, Strohmayer Lourencetti NM, Gomes PC, Ayusso GM, Dutra LA, Silva Bolzani VD, Regasini LO, Soares Mendes-Giannini MJ, Fusco-Almeida AM. Palanco AC, et al. Among authors: regasini lo. Future Microbiol. 2017 Oct;12:1123-1134. doi: 10.2217/fmb-2017-0062. Epub 2017 Sep 6. Future Microbiol. 2017. PMID: 28876122
Curcumin Analog CH-5 Suppresses the Proliferation, Migration, and Invasion of the Human Gastric Cancer Cell Line HGC-27.
Silva G, Teixeira Lima F, Seba V, Mendes Lourenço AL, Lucas TG, de Andrade BV, Torrezan GS, Polaquini CR, Garcia ME, Couto LB, Bestetti RB, de Castro França S, Fachin AL, Regasini LO, Marins M. Silva G, et al. Among authors: regasini lo. Molecules. 2018 Jan 30;23(2):279. doi: 10.3390/molecules23020279. Molecules. 2018. PMID: 29385675 Free PMC article.
113 results