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Anti-HLA antibodies with complementary and synergistic interaction geometries promote classical complement activation on platelets.
Rijkers M, Schmidt D, Lu N, Kramer CSM, Heidt S, Mulder A, Porcelijn L, Claas FHJ, Leebeek FWG, Jansen AJG, Jongerius I, Zeerleder SS, Vidarsson G, Voorberg J, de Haas M. Rijkers M, et al. Haematologica. 2019 Feb;104(2):403-416. doi: 10.3324/haematol.2018.201665. Epub 2018 Sep 27. Haematologica. 2019. PMID: 30262558 Free PMC article.
A subset of anti-HLA antibodies induces FcγRIIa-dependent platelet activation.
Rijkers M, Saris A, Heidt S, Mulder A, Porcelijn L, Claas FHJ, Bierings R, Leebeek FWG, Jansen AJG, Vidarsson G, Voorberg J, de Haas M. Rijkers M, et al. Haematologica. 2018 Oct;103(10):1741-1752. doi: 10.3324/haematol.2018.189365. Epub 2018 Jun 1. Haematologica. 2018. PMID: 29858387 Free PMC article.
Emerging Concepts in Immune Thrombocytopenia.
Swinkels M, Rijkers M, Voorberg J, Vidarsson G, Leebeek FWG, Jansen AJG. Swinkels M, et al. Among authors: rijkers m. Front Immunol. 2018 Apr 30;9:880. doi: 10.3389/fimmu.2018.00880. eCollection 2018. Front Immunol. 2018. PMID: 29760702 Free PMC article. Review.