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Discovery of (E)-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)propanamide (CHMFL-ABL-121) as a highly potent ABL kinase inhibitor capable of overcoming a variety of ABL mutants including T315I for chronic myeloid leukemia.
Liu X, Wang B, Chen C, Jiang Z, Hu C, Wu H, Zhang Y, Liu X, Wang W, Wang J, Hu Z, Wang A, Huang T, Liu Q, Wang W, Wang L, Wang W, Ren T, Li L, Xia R, Ge J, Liu Q, Liu J. Liu X, et al. Among authors: zhang y. Eur J Med Chem. 2018 Dec 5;160:61-81. doi: 10.1016/j.ejmech.2018.10.007. Epub 2018 Oct 5. Eur J Med Chem. 2018. PMID: 30317026
Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino)cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl)tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor.
Wang B, Wu J, Wu Y, Chen C, Zou F, Wang A, Wu H, Hu Z, Jiang Z, Liu Q, Wang W, Zhang Y, Liu F, Zhao M, Hu J, Huang T, Ge J, Wang L, Ren T, Wang Y, Liu J, Liu Q. Wang B, et al. Among authors: zhang y. Eur J Med Chem. 2018 Oct 5;158:896-916. doi: 10.1016/j.ejmech.2018.09.025. Epub 2018 Sep 13. Eur J Med Chem. 2018. PMID: 30253346
Mini review roles of the bZIP gene family in rice.
E ZG, Zhang YP, Zhou JH, Wang L. E ZG, et al. Among authors: zhang yp. Genet Mol Res. 2014 Apr 16;13(2):3025-36. doi: 10.4238/2014.April.16.11. Genet Mol Res. 2014. PMID: 24782137 Free article. Review.
Multi-year clinical outcomes of cancers diagnosed following detection by a blood-based multi-cancer early detection (MCED) test.
Buchanan AH, Lennon AM, Choudhry OA, Elias PZ, Rego SP, Sadler JR, Roberta J, Zhang Y, Flake DD, Salvati ZM, Wagner ES, Fishman EK, Papadopoulos N, Beer TM. Buchanan AH, et al. Among authors: zhang y. Cancer Prev Res (Phila). 2024 May 31. doi: 10.1158/1940-6207.CAPR-24-0107. Online ahead of print. Cancer Prev Res (Phila). 2024. PMID: 38819783
Enzyme-Programmed Self-Assembly of Nanoparticles.
Zhang Y, Liu X, Hou S, Wu R, Yang J, Zhang C. Zhang Y, et al. Chembiochem. 2024 May 31:e202400384. doi: 10.1002/cbic.202400384. Online ahead of print. Chembiochem. 2024. PMID: 38819745
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