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Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice.
Dowman JK, Hopkins LJ, Reynolds GM, Armstrong MJ, Nasiri M, Nikolaou N, van Houten EL, Visser JA, Morgan SA, Lavery GG, Oprescu A, Hübscher SG, Newsome PN, Tomlinson JW. Dowman JK, et al. Among authors: tomlinson jw. Endocrinology. 2013 Dec;154(12):4536-47. doi: 10.1210/en.2013-1592. Epub 2013 Sep 30. Endocrinology. 2013. PMID: 24080367 Free PMC article.
Glucocorticoids and non-alcoholic fatty liver disease.
Woods CP, Hazlehurst JM, Tomlinson JW. Woods CP, et al. Among authors: tomlinson jw. J Steroid Biochem Mol Biol. 2015 Nov;154:94-103. doi: 10.1016/j.jsbmb.2015.07.020. Epub 2015 Aug 1. J Steroid Biochem Mol Biol. 2015. PMID: 26241028 Review.
Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.
Hazlehurst JM, Oprescu AI, Nikolaou N, Di Guida R, Grinbergs AE, Davies NP, Flintham RB, Armstrong MJ, Taylor AE, Hughes BA, Yu J, Hodson L, Dunn WB, Tomlinson JW. Hazlehurst JM, et al. Among authors: tomlinson jw. J Clin Endocrinol Metab. 2016 Jan;101(1):103-13. doi: 10.1210/jc.2015-2928. Epub 2015 Nov 17. J Clin Endocrinol Metab. 2016. PMID: 26574953 Free PMC article. Clinical Trial.
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study.
Armstrong MJ, Gaunt P, Aithal GP, Barton D, Hull D, Parker R, Hazlehurst JM, Guo K; LEAN trial team; Abouda G, Aldersley MA, Stocken D, Gough SC, Tomlinson JW, Brown RM, Hübscher SG, Newsome PN. Armstrong MJ, et al. Among authors: tomlinson jw. Lancet. 2016 Feb 13;387(10019):679-690. doi: 10.1016/S0140-6736(15)00803-X. Epub 2015 Nov 20. Lancet. 2016. PMID: 26608256 Free article. Clinical Trial.
Non-alcoholic fatty liver disease and diabetes.
Hazlehurst JM, Woods C, Marjot T, Cobbold JF, Tomlinson JW. Hazlehurst JM, et al. Among authors: tomlinson jw. Metabolism. 2016 Aug;65(8):1096-108. doi: 10.1016/j.metabol.2016.01.001. Epub 2016 Jan 11. Metabolism. 2016. PMID: 26856933 Free PMC article. Review.
205 results