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Preclinical pharmacokinetics and biodistribution of subcutaneously administered glycoPEGylated recombinant factor VIII (N8-GP) and development of a human pharmacokinetic prediction model.
Rode F, Almholt K, Petersen M, Kreilgaard M, Kjalke M, Karpf DM, Groth AV, Johansen PB, Larsen LF, Loftager M, Haaning J. Rode F, et al. Among authors: kjalke m. J Thromb Haemost. 2018 Jun;16(6):1141-1152. doi: 10.1111/jth.14013. Epub 2018 May 10. J Thromb Haemost. 2018. PMID: 29582559 Free article.
A novel next-generation FVIIIa mimetic, Mim8, has a favorable safety profile and displays potent pharmacodynamic effects: Results from safety studies in cynomolgus monkeys.
Lauritzen B, Bjelke M, Björkdahl O, Bloem E, Keane K, Kjalke M, Rossen M, Lippert SL, Weldingh KN, Skydsgaard M, Kjellev S. Lauritzen B, et al. Among authors: kjalke m. J Thromb Haemost. 2022 Jun;20(6):1312-1324. doi: 10.1111/jth.15682. Epub 2022 Mar 6. J Thromb Haemost. 2022. PMID: 35191180 Free PMC article.
A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models.
Stennicke HR, Kjalke M, Karpf DM, Balling KW, Johansen PB, Elm T, Øvlisen K, Möller F, Holmberg HL, Gudme CN, Persson E, Hilden I, Pelzer H, Rahbek-Nielsen H, Jespersgaard C, Bogsnes A, Pedersen AA, Kristensen AK, Peschke B, Kappers W, Rode F, Thim L, Tranholm M, Ezban M, Olsen EH, Bjørn SE. Stennicke HR, et al. Among authors: kjalke m. Blood. 2013 Mar 14;121(11):2108-16. doi: 10.1182/blood-2012-01-407494. Epub 2013 Jan 18. Blood. 2013. PMID: 23335368 Free PMC article.
Purification and characterization of a new recombinant factor VIII (N8).
Thim L, Vandahl B, Karlsson J, Klausen NK, Pedersen J, Krogh TN, Kjalke M, Petersen JM, Johnsen LB, Bolt G, Nørby PL, Steenstrup TD. Thim L, et al. Among authors: kjalke m. Haemophilia. 2010 Mar;16(2):349-59. doi: 10.1111/j.1365-2516.2009.02135.x. Epub 2009 Nov 11. Haemophilia. 2010. PMID: 19906157
Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets.
Enoksson M, Martin EJ, Holmberg H, Jensen MS, Kjelgaard-Hansen M, Egebjerg T, Buchardt J, Krogh TN, Demuth H, Sanfridson A, Hilden I, Kjalke M, Brophy DF. Enoksson M, et al. Among authors: kjalke m. J Thromb Haemost. 2020 Jan;18(1):104-113. doi: 10.1111/jth.14644. Epub 2019 Oct 14. J Thromb Haemost. 2020. PMID: 31549480 Free article.
41 results